Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis

Metabolism: Clinical and Experimental
Stergios A PolyzosChristos S Mantzoros

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent disease and important unmet medical need. Current guidelines recommend, under specific restrictions, pioglitazone or vitamin E in patients with NASH and significant fibrosis, but the use of both remains off-label. We summarize evidence on medications for the treatment of nonalcoholic steatohepatitis (NASH), since NASH has been mainly associated with higher morbidity and mortality. Some of these medications are currently in phase 3 clinical trials, including obeticholic acid (a farnesoid X receptor agonist), elafibranor (a peroxisome proliferator activated receptor [PPAR]-α/δ dual agonist), cenicriviroc (a CC chemokine receptor antagonist), MSDC-0602 K (a PPAR sparing modulator), selonsertib (an apoptosis signal-regulating kinase-1 inhibitor) and resmetirom (a thyroid hormone receptor agonist). A significant research effort is also targeting PPARs and selective PPAR modulators, including INT131 and pemafibrate, with the expectation that novel drugs may have beneficial effects similar to those of pioglitazone, but without the associated adverse effects. Whether these and other medications could offer tangible therapeutic benefits, alone or in combination, apparently o...Continue Reading

Citations

Oct 2, 2020·PloS One·Kristine GriffettThomas P Burris
Oct 22, 2020·Journal of Clinical and Translational Hepatology·Tomislav KizivatMartina Smolic
Dec 19, 2020·Archives of Medical Research·Evangelia MakriStergios A Polyzos
Jan 31, 2021·Annals of Hepatology·Chanthawat PatikornNathorn Chaiyakunapruk
Jan 2, 2021·Journal of Digestive Diseases·Bo Shen, Lun Gen Lu
Mar 30, 2021·Journal of Experimental Pharmacology·Tsipora M HuismanScott L Friedman
Nov 22, 2020·Molecular Metabolism·Yang XiaoMitchell A Lazar
Apr 1, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Nikolaos PerakakisChristos S Mantzoros
Apr 27, 2021·Metabolism: Clinical and Experimental·Chrysoula BoutariChristos S Mantzoros
Apr 18, 2021·Metabolism: Clinical and Experimental·Emir MuzurovićChristos Mantzoros
Nov 26, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M KouvariUNKNOWN ATTICA study Investigators
Jun 4, 2021·Journal of Translational Medicine·Khaoula ErrafiiAbdelilah Arredouani
Jun 1, 2021·Frontiers in Chemistry·Aziz EftekhariMagali Cucchiarini
Jun 21, 2021·European Journal of Pharmacology·Evangelia S MakriStergios A Polyzos
Jul 3, 2021·International Journal of Molecular Sciences·Nikolaos PerakakisChristos S Mantzoros
Apr 4, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Samer GawriehNaga Chalasani
Jul 22, 2021·Journal of Gastroenterology and Hepatology·Victoria PotoupniStergios A Polyzos
Aug 21, 2021·Alimentary Pharmacology & Therapeutics·Stergios A PolyzosEmmanuel A Tsochatzis
Sep 27, 2021·Journal of Internal Medicine·Youngmin A Lee, Scott L Friedman

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