Current and emerging tests for the laboratory monitoring of chronic myeloid leukaemia and related disorders

Pathology
D M Ross, T P Hughes

Abstract

Chronic myeloid leukaemia (CML) is a molecularly defined disease. The BCR-ABL fusion occurs in all cases of classical CML and leukaemic cells express a constitutively activated BCR-ABL tyrosine kinase. Other fusion oncogenes involving tyrosine kinases, including ABL and PDGFRA/B, have been identified, and are associated with leukaemic syndromes that may resemble CML. The discovery and treatment of these related disorders has been facilitated by our detailed understanding of CML. Imatinib mesylate has significantly improved the outcome of patients with CML, but there remains a significant minority of chronic phase CML patients for whom the response to treatment with standard dose imatinib is suboptimal. Cytogenetic and molecular monitoring of the response to treatment provides important prognostic information. Achievement of a major molecular response (MMR) in chronic phase patients treated de novo with imatinib confers near 100% freedom from progression to advanced phase, and MMR is now an important goal of therapy. Standardisation of BCR-ABL molecular monitoring is under way and should enable the accurate and reproducible identification of MMR in laboratories around the world. Point mutations in the kinase domain of BCR-ABL ar...Continue Reading

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Citations

Dec 14, 2011·Pathology·Michelle McNiven, D Talaulikar
Jul 17, 2010·Cancer Genetics and Cytogenetics·S PrabhuA Smith
Jul 7, 2009·Hematology/oncology Clinics of North America·Dragan Jevremovic, David S Viswanatha
Mar 24, 2009·American Journal of Hematology·Carolina PavlovskyJorge E Cortes
May 2, 2009·Biochimica Et Biophysica Acta·Michael A Tainsky
Jul 1, 2012·Personalized Medicine·Mathew W MoorePhilip D Cotter

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