Current and future antithrombotic agents in children

Expert Review of Cardiovascular Therapy
G Young

Abstract

Thromboembolic complications are increasing in children, and the use of anticoagulation has seen a dramatic increase despite the lack of randomized clinical trials. The most widely used agents in children are heparin and warfarin, however these agents have limitations that are exaggerated in children. This has led to the use of newer agents with improved pharmacologic properties such as low-molecular-weight heparin, however, the use of novel agents such as direct thrombin inhibitors has been limited to case reports. These agents, however, have potential advantages over heparin, low-molecular-weight heparin and warfarin. Current clinical trials are in progress to define the proper dose of two such agents--argatroban (Argatroban, GlaxoSmithKline) and bivalirudin (Angiomax, The Medicines Company). The selective Factor Xa inhibitor fondaparinux (Arixtra, Sanofi-Synthelabo) has not been used in children; however, there are situations in which this agent may be advantageous. This review will discuss the currently available agents, with an emphasis on those that are novel and their potential uses in children.

References

Jul 1, 1991·Thrombosis Research·A VieiraM Andrew
Jun 27, 1991·The New England Journal of Medicine·J Hirsh
Jan 1, 1988·Seminars in Thrombosis and Hemostasis·M Andrew, B Schmidt
May 1, 1986·Thrombosis Research·A WoodsM A Lazzari
Jan 1, 1997·Seminars in Thrombosis and Hemostasis·A H SutorM Andrew
May 15, 1998·The Journal of Pediatrics·M AndrewM P Massicotte
Nov 20, 1998·Chest·A D MichelsonM Andrew
Apr 25, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·T GüntherR Lange
Apr 25, 2000·Journal of Pediatric Hematology/oncology·M P Massicotte
Apr 25, 2000·Journal of Pediatric Hematology/oncology·R C PunzalanJ C Gill
May 12, 2000·Hematology/oncology Clinics of North America·T KawadaJ Shiomura
Sep 30, 2000·Seminars in Thrombosis and Hemostasis·M M Samama, G T Gerotziafas
Jul 12, 2001·Seminars in Thrombosis and Hemostasis·T Severin, A H Sutor
Feb 28, 2002·The Journal of Pediatrics·Steven R DeitcherMaryanne R Kichuk-Chrisant
Apr 17, 2002·European Journal of Pediatrics·Manuela Albisetti, Maureen Andrew
Nov 7, 2002·Seminars in Thrombosis and Hemostasis·Gerd HafnerMatthias Nauck
Nov 7, 2002·Seminars in Thrombosis and Hemostasis·Norbert Lubenow, Andreas Greinacher
Nov 7, 2002·Seminars in Thrombosis and Hemostasis·Thomas SeverinAnton H Sutor
Feb 13, 2003·Pediatric Clinics of North America·Carolyn Hoppe, Alison Matsunaga
May 13, 2003·Expert Opinion on Pharmacotherapy·Karen L Kaplan
Sep 17, 2003·Journal of Internal Medicine·M M W Koopman, H R Büller
Nov 25, 2003·Heart Disease·Lenka HrebickovaJoe R Anderson
Dec 30, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Frank CettaJeanine M Walenga

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Citations

Jan 6, 2006·Journal of Pediatric Hematology/oncology·Marcie J HurstingCatherine N Verme-Gibboney
Sep 1, 2007·Journal of Pediatric Hematology/oncology·Anjali Alatkar SharathkumarSteven Pipe
Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·G YoungD J Nugent
May 27, 2008·Journal of Clinical Anesthesia·Alexander A VitinTiberiu Ezri
Jan 24, 2008·Pediatric Blood & Cancer·Ashley R MasonJohn Lazarchick
Apr 28, 2010·Journal of Clinical Pharmacology·Rajanikanth MadabushiJogarao V S Gobburu
Mar 8, 2006·Seminars in Fetal & Neonatal Medicine·Courtney Thornburg, Steven Pipe
Sep 13, 2015·Thrombosis Research·M E BaumanA A K Bruce
Nov 15, 2013·Circulation·Therese M GigliaUNKNOWN American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council
Dec 17, 2008·Hematology·Guy Young
Oct 6, 2005·Pediatric Blood & Cancer·Guy Young

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