Current and future applications of toxicogenomics: Results summary of a survey from the HESI Genomics State of Science Subcommittee.

Environmental Health Perspectives
Syril PettitAlison Vickers

Abstract

In spite of the application of toxicogenomic (TGx) data to the field of toxicology for the past 10 years, the broad implementation and full impact of TGx for chemical and drug evaluation to improve decision making within organizations and by policy makers has not been achieved. The goal of the Health and Environmental Sciences Institute (HESI) Committee on the Application of Genomics to Mechanism-based Risk Assessment was to construct and summarize a multisector survey, addressing key issues and perspectives on the current and future practical uses and challenges of implementing TGx data to facilitate discussions for decision making within organizations and by policy makers. An online survey to probe the current status and future challenges facing the field of TGx for drug and chemical evaluation in experimental and nonclinical models was taken by scientists and scientific decision/policy makers actively engaged in the field of TGx within industrial, academic, and regulatory sectors of the United States, Europe, and Japan. For this survey, TGx refers specifically to the analysis of gene expression responses to evaluate xenobiotic exposure in experimental and preclinical models. The survey results are summarized from questions c...Continue Reading

References

Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Holly K DressmanJohnathan M Lancaster
Jul 13, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S P RiveraO Hankinson
Jul 27, 2007·Toxicologic Pathology·William R FosterBruce D Car
Aug 19, 2007·Expert Opinion on Drug Metabolism & Toxicology·Timothy W Gant
Jan 2, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Caroline RimkusJörg Rüdiger Siewert

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Citations

Feb 8, 2011·Toxicology and Applied Pharmacology·Vickie S WilsonSusan Y Euling
Apr 4, 2012·Expert Opinion on Drug Discovery·Craig E Thomas, Yvonne Will
Aug 16, 2011·Regulatory Toxicology and Pharmacology : RTP·Amber K GoetzErik R Janus
Jul 18, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Vera van der VelpenAnouk Geelen
Jan 17, 2020·Integrated Environmental Assessment and Management·Matthieu MondouNiladri Basu
Jul 14, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeliyah ClarkJulia E Rager

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Methods Mentioned

BETA
array technology
PCR

Software Mentioned

MIAME
SurveyMonkey

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