Current and future centrally acting antitussives

Respiratory Physiology & Neurobiology
Donald C Bolser

Abstract

The purpose of this review is to highlight some important issues regarding current centrally acting antitussive drugs as well as discuss the implications of these matters on the development of future cough suppressants. Drugs that act in the central nervous system to inhibit cough are termed centrally acting and this designation is based exclusively on evidence obtained from animal models. This classification can include drugs that act both at peripheral and central sites following systemic administration. These drugs are intended to reduce the frequency and/or intensity of coughing resulting from disorders of any etiology. There are a number of central cough suppressants identified by their efficacy in animal models and the most prominent of these are codeine and dextromethorphan. Although the exact neural elements on which these drugs act are currently unknown, they are thought to inhibit a functionally identified component of the central system for cough known as the gating mechanism. The efficacy of codeine and dextromethorphan in humans has recently been questioned. These drugs are less effective on cough induced by upper airway disorders than in pathological conditions involving the lower airways in humans. The reasons fo...Continue Reading

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Citations

May 5, 2011·Pharmacology, Biochemistry, and Behavior·Elke Griesmaier, Matthias Keller
Mar 12, 2010·Journal of Ethnopharmacology·Yan-Tong XuPaul Pui-Hay But
Jul 29, 2009·Pulmonary Pharmacology & Therapeutics·E D BatemanI Wessler
Oct 29, 2008·Pharmazie in unserer Zeit·Kerstin SanderHolger Stark
Jun 3, 2006·Respiratory Physiology & Neurobiology·Brendan J CanningStuart B Mazzone
Jul 14, 2016·The Cochrane Database of Systematic Reviews·Samantha J GardinerHelen L Petsky
Sep 13, 2011·Epilepsia·Melodie R WinawerAbraham A Palmer
May 13, 2020·Drug Metabolism Reviews·Ana Rita Silva, Ricardo Jorge Dinis-Oliveira
Mar 23, 2021·Frontiers in Physiology·Wendy L OlsenDonald C Bolser
Nov 2, 2021·The Journal of Organic Chemistry·Hai-Lian YuanXiao-Dong Luo

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