PMID: 9546977Jan 1, 1997Paper

Current and future drug therapies for claudication

Vascular Medicine
William R Hiatt

Abstract

The primary objectives of claudication treatment are to reduce cardiovascular mortality and improve walking ability. Patients with claudication have 60% mortality over 10 years, with most deaths due to myocardial infarction and stroke. Aggressive risk-factor modification is required in all these patients, particularly smoking cessation, lipid modification, and treatment of hypertension, diabetes and elevated homocysteine levels. Aspirin, ticlopidine and clopidogrel are all effective in reducing the risk of myocardial infarction, stroke and vascular death, and thus antiplatelet therapy should be considered in all claudicants. Patients with disabling claudication should be considered for therapies that relieve claudication pain and improve exercise performance, the most effective being exercise training and smoking cessation. Pentoxifylline, the only approved claudication drug in the United States, has modest efficacy in improving treadmill exercise performance. Other drugs shown to be of some benefit in patients with claudication include propionyl-L-carnitine, cilostazol and possibly prostaglandin derivatives. Several antiplatelet agents and angiogenic growth factors are also being evaluated for the treatment of claudication.

References

Mar 29, 1979·The New England Journal of Medicine·J D Coffman
Jul 1, 1992·Journal of Applied Physiology·W R HiattE P Brass
Mar 1, 1992·Journal of Internal Medicine·B GuldagerS Ottesen
Aug 22, 1991·The New England Journal of Medicine·S R TunisE P Steinberg
Feb 1, 1991·Circulation·D H BlankenhornE C Wickham
Apr 25, 1991·The New England Journal of Medicine·R ClarkeI Graham
May 1, 1991·Annals of Vascular Surgery·W C Krupski
Jan 1, 1990·Journal of Clinical Epidemiology·W R HiattR F Hamman
Jan 1, 1988·Annual Review of Biochemistry·L L Bieber
Nov 1, 1986·British Medical Journal·R JelnesT Schroeder
Feb 1, 1988·European Journal of Vascular Surgery·P S OlsenJ E Lorentzen
Jan 1, 1985·Journal of the American Geriatrics Society·W B Kannel, D L McGee
Jan 1, 1982·Acta Medica Scandinavica·A ReunanenA Aromaa
Nov 15, 1995·Journal of the American College of Cardiology·G BrevettiM Condorelli
Jun 1, 1996·Journal of Cardiovascular Pharmacology·M LievreJ P Boissel
Mar 15, 1997·The American Journal of Cardiology·G BrevettiG Barletta
Aug 27, 1960·British Medical Journal·A SINGER, C ROB

❮ Previous
Next ❯

Citations

Oct 12, 1999·Circulation·M J Quinn, D J Fitzgerald
Dec 8, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Miranda FongYongge Liu
Jun 13, 2003·Family & Community Health·Daniel I GalperDaniel J Cox
Nov 1, 2002·Clinical Drug Investigation·Giuseppe Maria AndreozziAlessandra D'Eri
Nov 1, 2000·Der Internist·C DiehmW Theiss
Jan 10, 2003·The Cochrane Database of Systematic Reviews·M V VillarruzF Tan
May 6, 2020·The Cochrane Database of Systematic Reviews·Maria Vanessa Villarruz-SulitDennis V Sulit

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
D E Hilleman
Journal of the American College of Cardiology
Seung-Whan LeeSeung-Jung Park
Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing
Rachelle L Muir
© 2022 Meta ULC. All rights reserved