Current and Future Outlook on Disease Modification and Defining Low Disease Activity in Systemic Sclerosis.

Arthritis & Rheumatology
Vivek NagarajaDinesh Khanna

Abstract

Systemic sclerosis (SSc) is an autoimmune rheumatic disease with heterogeneous clinical manifestations and a variable course in which the severity of the pathology dictates the disease prognosis and course. Among autoimmune rheumatic diseases, SSc has the highest mortality rate among all rheumatic diseases, though there are exciting new therapeutic targets that appear to halt the progression of SSc manifestations such as skin or lung fibrosis. In selected patients, high-intensity regimens with autologous stem cell transplantation can favorably modify the course. In what was once thought to be an untreatable disease, targeted therapies have now changed the outlook of SSc to a treatable disorder. Herein, we discuss the targeted therapies modifying the outlook on selected organ involvement and creating opportunities for future treatment. We also present a framework for defining low disease activity in SSc.

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Citations

Aug 3, 2020·Current Opinion in Pulmonary Medicine·Ciaran J ScallanGanesh Raghu
Oct 16, 2020·Expert Opinion on Emerging Drugs·David RoofehDinesh Khanna
Mar 21, 2021·Current Opinion in Rheumatology·David RoofehDinesh Khanna
Aug 8, 2021·Nature Reviews. Rheumatology·Yumeko Kawano, Lorinda Chung
Aug 18, 2021·Current Opinion in Rheumatology·Nicholas A Flavahan

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