Current and future perspectives in the management of juvenile idiopathic arthritis

The Lancet Child & Adolescent Health
Nicolino Ruperto, Alberto Martini

Abstract

The treatment of juvenile idiopathic arthritis has improved tremendously in the past 20 years as a result of appropriate legislative initiatives, large international collaborative networks, and the availability of new potent medications. Despite these considerable advances, a sizable proportion of patients are still resistant to treatment. Further improvement will stem from a better definition of the disease entities under the broad term juvenile idiopathic arthritis (which includes all forms of arthritis with disease onset before the age of 16 years); the discovery of laboratory and imaging biomarkers that could help the tuning of therapy; smoother implementation of clinical trials; more standardised links between academia, regulatory authorities, and patient organisations for the planning of future trials; and the availability of new drugs that selectively target molecules or pathways involved in inflammation.

Citations

Oct 9, 2020·Paediatric Drugs·Hermine I BrunnerUNKNOWN Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group
Aug 13, 2020·Arthritis & Rheumatology·Pierre QuartierUNKNOWN Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group
Jan 26, 2021·Rheumatology·Nicolino RupertoUNKNOWN Pediatric Rheumatology Collaborative Study Group (PRCSG) and the Paediatric Rheumatology International Trials Organisation (
Mar 9, 2021·Current Rheumatology Reports·Gabriella GiancaneNicolino Ruperto
Mar 19, 2021·Nature Reviews. Rheumatology·Peter A NigrovicAlberto Martini
Aug 25, 2021·Pediatric Rheumatology Online Journal·Lina N ZaripovaRachel A Oldershaw
Jan 29, 2022·Nature Reviews. Disease Primers·Alberto MartiniNicolino Ruperto

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