Current and Future Role of Tyrosine Kinases Inhibition in Thyroid Cancer: From Biology to Therapy.

International Journal of Molecular Sciences
María San Román GilTeresa Alonso-Gordoa

Abstract

Thyroid cancer represents a heterogenous disease whose incidence has increased in the last decades. Although three main different subtypes have been described, molecular characterization is progressively being included in the diagnostic and therapeutic algorithm of these patients. In fact, thyroid cancer is a landmark in the oncological approach to solid tumors as it harbors key genetic alterations driving tumor progression that have been demonstrated to be potential actionable targets. Within this promising and rapid changing scenario, current efforts are directed to improve tumor characterization for an accurate guidance in the therapeutic management. In this sense, it is strongly recommended to perform tissue genotyping to patients that are going to be considered for systemic therapy in order to select the adequate treatment, according to recent clinical trials data. Overall, the aim of this article is to provide a comprehensive review on the molecular biology of thyroid cancer focusing on the key role of tyrosine kinases. Additionally, from a clinical point of view, we provide a thorough perspective, current and future, in the treatment landscape of this tumor.

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Citations

May 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Mimi I HuRichard T Kloos

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Methods Mentioned

BETA
Transfection
genotyping
biopsy

Clinical Trials Mentioned

NCT01876784
NCT04211337
NCT02628067
NCT03181100
NCT03914300
NCT01346358
NCT01525602
NCT02452424
NCT02718911
NCT01947023

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