Current and future therapies for addressing the effects of inflammation on HDL cholesterol metabolism

British Journal of Pharmacology
Fatima IqbalDemidmaa Tuvdendorj


Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Inflammatory processes arising from metabolic abnormalities are known to precipitate the development of CVD. Several metabolic and inflammatory markers have been proposed for predicting the progression of CVD, including high density lipoprotein cholesterol (HDL-C). For ~50 years, HDL-C has been considered as the atheroprotective 'good' cholesterol because of its strong inverse association with the progression of CVD. Thus, interventions to increase the concentration of HDL-C have been successfully tested in animals; however, clinical trials were unable to confirm the cardiovascular benefits of pharmaceutical interventions aimed at increasing HDL-C levels. Based on these data, the significance of HDL-C in the prevention of CVD has been called into question. Fundamental in vitro and animal studies suggest that HDL-C functionality, rather than HDL-C concentration, is important for the CVD-preventive qualities of HDL-C. Our current review of the literature positively demonstrates the negative impact of systemic and tissue (i.e. adipose tissue) inflammation in the healthy metabolism and function of HDL-C. Our survey indicates that HDL-C may be a good...Continue Reading


Jul 1, 1976·The Journal of the American Dental Association·A H Gartner
Feb 5, 1976·The New England Journal of Medicine·G G RhoadsA Kagan
Jan 1, 1991·Mayo Clinic Proceedings·J A EtchasonB A Kottke
May 1, 1989·Respiratory Medicine·J Eason, H L Markowe
Oct 1, 1966·Circulation·J W GofmanR Tandy
Sep 1, 1993·Atherosclerosis·E MalleJ G Raynes
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·A S PlumpJ L Breslow
May 1, 1996·Southern Medical Journal·Naga ChalasaniR L Jurado
Apr 3, 1997·The New England Journal of Medicine·Paul M RidkerC H Hennekens
Mar 1, 1997·The Proceedings of the Nutrition Society·C M Williams
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaYuji Matsuzawa
Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Dobiásová, J J Frohlich
Dec 10, 1999·Journal of Thrombosis and Thrombolysis·D FengG H Tofler
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaYuji Matsuzawa
Nov 18, 2000·Cellular Signalling·T ChakrabortiS Chakraborti
Nov 23, 2000·Genes & Development·J R SchultzB Shan
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·P A KernG Ranganathan
Jun 8, 2001·The Journal of Clinical Investigation·G MartinBart Staels
Jul 17, 2001·Annals of the Rheumatic Diseases·M CutoloR H Straub
Aug 17, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H ImachiJ Takahara
Oct 12, 2001·Immunologic Research·R F Mortensen
Nov 6, 2001·The Journal of Biological Chemistry·Mikael RydenPeter Arner
Mar 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Shirya RashidGary F Lewis
Jun 7, 2002·Clinical and Experimental Medicine·A L PasquiA Auteri
Jun 28, 2002·Clinical Rheumatology·A YildirirS Kes
Jul 11, 2002·European Journal of Pharmacology·Rainer Amann, Bernhard A Peskar
Jan 14, 2003·Nature Medicine·Sean B JosephPeter Tontonoz
Feb 1, 2003·BMJ : British Medical Journal·Michael Sosin, Sunil Handa
May 20, 2003·Journal of Lipid Research·Soazig Le LayIsabelle Dugail
Jun 26, 2003·American Journal of Physiology. Endocrinology and Metabolism·S M TurnerM K Hellerstein
Dec 18, 2003·The Journal of Clinical Investigation·Haiyan XuHong Chen
Jan 8, 2004·European Journal of Pharmacology·Salvatore CuzzocreaChristoph Thiemermann
Mar 10, 2004·The American Journal of Medicine·Robert S Rosenson
Mar 23, 2004·Biochemical and Biophysical Research Communications·Hirohito SoneNobuhiro Yamada
Apr 9, 2004·The New England Journal of Medicine·Margaret E BrousseauDaniel J Rader
Dec 30, 2004·The Journal of Clinical Endocrinology and Metabolism·Kajsa SjöholmLena M S Carlsson
Jan 15, 2005·Current Opinion in Lipidology·Ji-Young Lee, John S Parks
Apr 21, 2005·The Journal of Clinical Investigation·Jenelle M TimminsJohn S Parks
May 12, 2005·JAMA : the Journal of the American Medical Association·Hakon HakonarsonKari Stefansson
May 14, 2005·Circulation Research·Anders H Berg, Philipp E Scherer
Aug 17, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Gursev S Dhaunsi
Feb 4, 2006·Current Atherosclerosis Reports·Ernst J Schaefer, Bela F Asztalos
Feb 28, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Vassilis I ZannisMonty Krieger
Apr 28, 2006·Scandinavian Journal of Rheumatology·S Rantapää DahlqvistO Johnson
Jun 24, 2006·Atherosclerosis·Nalini Santanam, Sampath Parthasarathy
Jul 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ivan TancevskiAndreas Ritsch
Jul 27, 2006·Allergy·W J Pichler
Dec 22, 2006·Journal of Lipid Research·Bela F AsztalosLaura Calabresi
Mar 29, 2007·Molecular and Cellular Biochemistry·Philip B VergheseJose L Soulages
May 23, 2007·The New England Journal of Medicine·Steven E Nissen, Kathy Wolski
May 31, 2007·Diabetes Care·Sonal SinghCurt D Furberg
Sep 25, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Martin SoubrierJean Michel Ristori
Oct 16, 2007·FEBS Letters·Hiroyuki OkuShizuya Yamashita
Nov 7, 2007·The New England Journal of Medicine·Philip J BarterILLUMINATE Investigators
Nov 15, 2007·The Journal of Pharmacology and Experimental Therapeutics·Akbar JafarnejadMohammad Z Hassan
Jan 17, 2008·Obesity·Shirya Rashid, Jacques Genest
Feb 22, 2008·Nature·Daniel J Rader, Alan Daugherty
Nov 28, 2008·Cardiovascular Therapeutics·Jerzy Bełtowski
Nov 28, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Elizabeth Carreón-TorresOscar Pérez-Méndez
Dec 17, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Yoon K LokeCurt D Furberg
Dec 19, 2008·The Journal of Nutrition·Isabelle DemontyElke A Trautwein
Feb 10, 2009·Atherosclerosis·Masaki OgataShinji Yokoyama
Mar 24, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Muhammad Haroon, Joe Devlin
Jul 29, 2009·Nature Reviews. Endocrinology·Terry A Jacobson
Dec 22, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Sylvain MathieuMartin Soubrier
Jan 23, 2010·Cardiovascular Drugs and Therapy·Robert S Rosenson
Mar 4, 2010·Nature Reviews. Rheumatology·Edwin S L Chan, Bruce N Cronstein
Mar 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raquel HorrilloJoan Clària
Mar 10, 2010·Circulation·YuZhen ZhangMuredach P Reilly
Mar 12, 2010·American Journal of Physiology. Cell Physiology·Lesley E SmythiesGeeta Datta
Mar 23, 2010·Nature Reviews. Drug Discovery·Trevor T HanselAndrew J T George
Jun 29, 2010·Journal of the American College of Cardiology·Michael PignoneAmerican College of Cardiology Foundation
Aug 13, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jean-Daniel Lalau
Oct 26, 2010·Journal of Lipid Research·John S MillarDaniel J Rader
Nov 12, 2010·Trends in Endocrinology and Metabolism : TEM·Scott M GordonW S Davidson
Nov 13, 2010·Circulation Research·Matthew Spite, Charles N Serhan
Nov 16, 2010·Journal of Clinical Lipidology·Jonathan D Smith
Jan 14, 2011·The New England Journal of Medicine·Amit V KheraDaniel J Rader
Mar 9, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kamran GhoreschiJohn J O'Shea
Apr 15, 2011·Cholesterol·Eric CoomesAllison B Reiss
May 4, 2011·Current Opinion in Lipidology·Bela F AsztalosErnst J Schaefer
Jul 5, 2011·Archives of Medical Research·Paul Jan Willem Herman KappelleRobin Pieter Frank Dullaart
Nov 17, 2011·The New England Journal of Medicine·William E BodenWilliam Weintraub
Dec 20, 2011·Biochimica Et Biophysica Acta·Kimberly A EdgelRenée C Leboeuf
Dec 23, 2011·Journal of Lipid Research·Ailing JiDeneys R van der Westhuyzen
Jan 10, 2012·Cell Metabolism·Rinke StienstraMihai G Netea
Aug 10, 2012·The New England Journal of Medicine·Ronald F van VollenhovenORAL Standard Investigators
Sep 8, 2012·Journal of Lipid Research·L Maria BelalcazarLook AHEAD Research Group
Sep 20, 2012·JAMA : the Journal of the American Medical Association·Ted D AdamsSteven C Hunt
Nov 3, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Urmila Maitra, Liwu Li
Nov 7, 2012·The New England Journal of Medicine·Gregory G Schwartzdal-OUTCOMES Investigators
Jan 17, 2013·Respiratory Care·Cenk AypakSüleyman Görpelioğlu
Jan 29, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·M FerwanaM H Murad
May 22, 2013·International Journal of Endocrinology·Heriberto Rodríguez-HernándezMiguel A Reyes-Romero
Jul 16, 2013·Journal of Cellular Biochemistry·Bai-mei HeZhen-yu Peng
Aug 29, 2013·American Journal of Physiology. Endocrinology and Metabolism·Demidmaa TuvdendorjNicola Abate
Oct 2, 2013·Journal of Clinical Lipidology·Peter P TothDaniel J Rader
Oct 17, 2013·Diabetes Care·Allison B GoldfineTINSAL-FMD (Targeting Inflammation Using Salsalate in Type 2 Diabetes–Flow-Mediated Dilation) Ancillary Study Team
Jan 21, 2014·Journal of Lipid Research·Willeke de HaanMichael R Hayden
Feb 18, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anthony BrehmRobert Foronjy
Apr 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark W RussoHerbert L Bonkovsky
May 20, 2014·The New England Journal of Medicine·Jonathon D TruwitB Taylor Thompson
May 21, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Peter P TothMaciej Banach
Jul 26, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Ailing JiDeneys R van der Westhuyzen
Jul 31, 2014·The Journal of Biological Chemistry·Michael C Phillips
Aug 12, 2014·Journal of Clinical Lipidology·W Virgil BrownPeter P Toth
Oct 17, 2014·Science Translational Medicine·Keith R WalleyJohn H Boyd
Dec 2, 2014·Bioorganic & Medicinal Chemistry Letters·Ellen KickRaju Mohan
Dec 20, 2014·Handbook of Experimental Pharmacology·Sophie ColinBart Staels
Feb 14, 2015·Bioorganic & Medicinal Chemistry Letters·Takayuki MatsudaKimiyuki Shibuya
Mar 17, 2015·Journal of Lipid Research·Morgan D FullertonGregory R Steinberg
Apr 18, 2015·International Journal of Cardiology·Amirhossein SahebkarLipid and Blood Pressure Meta-analysis Collaboration Group
Jun 25, 2015·BioMed Research International·Wajiha J KheirRola N Hamam
Sep 26, 2015·Brain Research·Ana Karolina Santana NunesChristina Alves Peixoto
Nov 10, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshinari UeharaKeijiro Saku
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderCGTP Collaborators
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderCGTP Collaborators
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderCGTP Collaborators
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderCgtp Collaborators
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderCGTP Collaborators
Jan 23, 2016·Clinical Biochemistry·Eduardo Ottobelli ChielleMaria Beatriz Moretto
Mar 5, 2016·Stroke; a Journal of Cerebral Circulation·Ihab Abd-ElrahmanGalia Blum
Mar 8, 2016·Chemico-biological Interactions·Anabel Garcia-HerediaJordi Camps
Apr 18, 2016·Metabolism: Clinical and Experimental·Ronald B GoldbergDiabetes Prevention Program Research Group
Apr 24, 2016·Biochimica Et Biophysica Acta·Markus TriebGunther Marsche
May 28, 2016·Scientific Reports·Manon DomiseValérie Vingtdeux
Jul 8, 2016·International Heart Journal·Ataru IgarashiHiroshi Watanabe
Aug 12, 2016·Metabolic Syndrome and Related Disorders·Sasa DusanovSerena Tonstad
Sep 1, 2016·Journal of Clinical Lipidology·Eliot A BrintonJerome D Cohen
Sep 16, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Donna Lee M DinnesLeonard Kritharides
Sep 17, 2016·Current Clinical Pharmacology·Jordi CampsJorge Joven
Oct 4, 2016·Archives of Medical Science : AMS·Wang Li LiNiu Nan
Oct 27, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W S DavidsonA S Shah
Nov 8, 2016·Expert Review of Respiratory Medicine·Kevin A Cook, Donald D Stevenson
Nov 30, 2016·European Journal of Pharmacology·Haowen ZhangXiaohu Chen


Nov 7, 2019·Journal of Lipid Research·Yuichiro NishidaJapan Multi-Institutional Collaborative Cohort Study Group
May 15, 2018·Nutrients·Alexandros TsouprasIoannis Zabetakis
Jul 16, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Fatima IqbalDemidmaa Tuvdendorj
Oct 29, 2017·British Journal of Pharmacology·Pasquale Maffia, Giuseppe Cirino
Dec 4, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Juan G Juárez-RojasEsteban Jorge-Galarza
Jan 26, 2021·Journal of Lipid Research·Yuichiro NishidaJapan Multi-Institutional Collaborative Cohort Study Group

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