Current and future treatment modalities in schizophrenia: novel antipsychotic drugs and cognitive therapy

Expert Review of Neurotherapeutics
Peter J McKenna, Ann M Mortimer

Abstract

In 60 years of use of antipsychotic drugs in schizophrenia, the only definite advance has been the introduction of clozapine. Some but not all other atypical or second-generation drugs may have small therapeutic advantages over conventional antipsychotics, but this remains controversial. New entrant atypicals seem unlikely to be therapeutically superior to conventional drugs, and glutamatergic drugs have yet to fulfill their theoretical promise. There is considerable current interest in novel mechanisms of antipsychotic action, but no such drugs have yet reached market authorization. A psychotherapeutic intervention, cognitive behavioral therapy has also found a place in the treatment of schizophrenia. However, the size of its effect against psychotic symptoms is small, and current evidence suggests no effect against negative symptoms or in reducing relapse.

References

Apr 29, 2014·Psychiatry Research·Oriana BianchiniAlessandro Serretti
May 16, 2020·The Cochrane Database of Systematic Reviews·Ghazaleh AaliFarhad Shokraneh

Citations

Jan 1, 1990·Schizophrenia Bulletin·H D BrennerK K Midha
Nov 28, 1997·The British Journal of Psychiatry : the Journal of Mental Science·Elizabeth KuipersC Hadley
Mar 7, 1998·Journal of Consulting and Clinical Psychology·D L Chambless, S D Hollon
Jul 7, 2001·BMJ : British Medical Journal·P JüniM Egger
Jun 4, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Douglas TurkingtonInsight into Schizophrenia Research Group
Jun 11, 2003·Archives of General Psychiatry·J M DavisIra D Glick
Nov 25, 2004·Schizophrenia Research·Harri J TuominenKristian Wahlbeck
Apr 14, 2005·Journal of Clinical Psychology·Irving Kirsch
Apr 19, 2005·Mental Health Services Research·Peter S JensenEliot Goldman
Sep 21, 2005·The New England Journal of Medicine·Jeffrey A LiebermanClinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators
Dec 6, 2006·Molecular Psychiatry·T J RaedlerB Dean
Jun 3, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Philippa A GaretyElizabeth Kuipers
Nov 14, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeffrey A LiebermanMEM-MD-29 Study Group
Mar 28, 2009·The Journal of Clinical Psychiatry·John F M GleesonPatrick D McGorry
Apr 2, 2009·Psychological Medicine·S LeuchtJ M Davis
Dec 25, 2009·CNS Drugs·Emma D Deeks, Gillian M Keating
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Patrik RoserWolfram Kawohl
Jul 6, 2010·The Psychiatric Clinics of North America·Shanaya RathodDavid Kingdon
Nov 30, 2010·The Journal of Experimental Biology·Alfredo OliverosElliott Richelson
Jan 5, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Mark van der GaagDurk Wiersma
Aug 5, 2011·The American Journal of Psychiatry·Jeffrey A Lieberman, T Scott Stroup
Dec 22, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Tim Kendall
Apr 28, 2012·Bioorganic & Medicinal Chemistry Letters·Eva Agai-CsongorZsolt Szombathelyi
Sep 19, 2012·Schizophrenia Bulletin·Daniel C Javitt
Dec 25, 2012·CNS Drugs·Mark Sanford
May 3, 2013·JAMA Psychiatry·Munish Aggarwal, Debasish Basu
Feb 1, 2011·Therapeutic Advances in Psychopharmacology·James M Stone

Related Concepts

Antipsychotic Effect
Enzyme Inhibitor Drugs
Schizophrenia
Clozapine
Antipsychotic Agents
Pharmacologic Substance
Psychotic Disorders
Cognitive Therapy
Glutamate Agents
Recurrent Disease

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Primary Care Companion to the Journal of Clinical Psychiatry
Raphael J. Leo, Paula Del Regno
Ugeskrift for laeger
Gertrud Krarup
Psychiatria Danubina
Klementina RuzićDaniela Petrić
© 2020 Meta ULC. All rights reserved