PMID: 8449849Feb 1, 1993Paper

Current and future trends in immunization against meningitis

The Journal of Antimicrobial Chemotherapy
D M Jones

Abstract

The progress in vaccines for Haemophilus influenzae type b infection is followed; it is the disadvantages of pure polysaccharide vaccines that have stimulated the development of the present generation of polysaccharide-protein conjugated vaccines. From extensive clinical trials it is apparent that these are very effective in preventing disease in children. Conjugated haemophilus vaccines were introduced into the routine immunization schedules in the UK in Autumn 1992. Meningococcal A and C polysaccharide vaccines, effective for epidemic disease, are only now being developed in a protein conjugated form with the prospect of protecting young children and producing durable immunity. Group B outer membrane-based meningococcal vaccines produce only a low degree of protection and much further work is needed before even the optimum vaccine constituents of this organism can be identified. Vaccines to replace multivalent pneumococcal polysaccharide mixtures are only in the very earliest stages of development.

Citations

Nov 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J Z Jordens, M P Slack
Mar 6, 1997·The New England Journal of Medicine·V J Quagliarello, W M Scheld
Jan 28, 2005·The Cochrane Database of Systematic Reviews·M Patel, C K Lee
Sep 8, 1998·Immunological Investigations·K R DiakunS Quataert
Aug 1, 1997·Immunological Investigations·K R DiakunS Quataert
Jan 1, 1994·Scandinavian Journal of Infectious Diseases·M SuriI C Verma

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