Current and future trends in therapy for dyslipidemias.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
H R Superko

Abstract

To characterize the atherogenic lipoprotein profile and discuss its implications in terms of treatment. Findings from large clinical trials and personal series of patients are reviewed, and the effectiveness of various interventions is assessed. A cost analysis of management of patients with dyslipidemias is offered. The dyslipidemia associated with non-insulin-dependent diabetes mellitus (NIDDM) is similar to low-density lipoprotein (LDL) pattern B. This atherosclerosis susceptibility trait--which typically consists of a preponderance of small dense LDL particles, intermediate-density lipoprotein, slightly increased triglycerides, and inappropriately low high-density lipoprotein type 2-- tends to precede the actual diagnosis of NIDDM and to identify a group with increased risk for cardiovascular events. It also usually signifies a group with good responses to treatment, including arteriographic evidence of regression of coronary artery disease. In general, niacin and fibrates are superior to statins for treatment of patients with LDL pattern B. Lipid management has been proved to be a cost-effective treatment strategy. Therapeutic options that lower triglyceride-rich lipoproteins and small dense LDL should be recommended in pa...Continue Reading

References

Dec 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K R FeingoldR M Krauss
Jun 19, 1987·JAMA : the Journal of the American Medical Association·D H BlankenhornL Cashin-Hemphill
Oct 1, 1994·Current Opinion in Lipidology·R M Krauss
Nov 15, 1996·Circulation·H R Superko

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Citations

Jun 15, 2004·International Journal of Cardiology·F BruniL Puccetti
Nov 1, 1998·The Physician and Sportsmedicine·T L Mitchell, L W Gibbons
Jul 9, 2002·Diabetes, Obesity & Metabolism·J PanM A Charles

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