Current and future use of nucleo(s)tide prodrugs in the treatment of hepatitis C virus infection

Antiviral Chemistry & Chemotherapy
Cyril B Dousson

Abstract

This review describes the current state of discovery of past most important nucleoside and nucleotide prodrugs in the treatment of hepatitis C virus infection as well as future potential drugs currently in discovery or clinical evaluation. I highlight first generation landmark prodrug compounds which have been the foundations of incremental improvements toward the discovery and approval milestone of Sofosbuvir. Sofosbuvir is the first nucleotide prodrug marketed for hepatitis C virus treatment and the backbone of current combination therapies. Since this approval, new nucleotide prodrugs using the same design of Sofosbuvir McGuigan prodrug have emerged, some of them progressing through advanced clinical trials and may become available as new incremental alternative hepatitis C virus treatments in the future. Although since Sofosbuvir success, only minimal design efforts have been invested in finding better liver targeted prodrugs, a few novel prodrugs are being studied and their different modes of activation may prove beneficial over the heart/liver targeting ratio to reduce potential drug-drug interaction in combination therapies and yield safer treatment to patients. Prodrugs have long been avoided as much as possible in the ...Continue Reading

References

Sep 4, 2009·Journal of Medicinal Chemistry·Cristina GardelliFrank Narjes
Jul 20, 2010·Bioorganic & Medicinal Chemistry Letters·Christopher McGuiganGeoffrey Henson
Aug 31, 2010·The Journal of Biological Chemistry·Eisuke MurakamiPhillip A Furman
Nov 3, 2010·Antiviral Therapy·Drew R BobeckSteven J Coats
Aug 23, 2011·Bioorganic & Medicinal Chemistry Letters·Christopher McGuiganStanley Chamberlain
Jul 28, 2013·Advances in Pharmacology·Michael J Sofia
Nov 28, 2013·Antiviral Research·Steven J CoatsRaymond F Schinazi
Aug 22, 2014·Chemical Reviews·Ugo PradereRaymond F Schinazi
May 10, 2016·ChemMedChem·Youcef Mehellou
Feb 22, 2017·Mini Reviews in Medicinal Chemistry·Marcela Krecmerova

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Citations

Jan 19, 2019·Pharmaceutical Patent Analyst·Marcella Bassetto, Magdalena Slusarczyk
Nov 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jin-Ching LeeChih-Hua Tseng
Dec 11, 2020·Antiviral Chemistry & Chemotherapy·Johanna Huchting
Mar 13, 2021·European Journal of Medicinal Chemistry·Anne-Laure VillardChristian Périgaud
Oct 15, 2019·The Journal of Organic Chemistry·Hyejin LeeLak Shin Jeong
Aug 31, 2021·Nucleosides, Nucleotides & Nucleic Acids·Monika TvrdoňováJozef Gonda

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