Current and future uses of neuroimaging for cognitively impaired patients.

Lancet Neurology
Gary W SmallJorge R Barrio

Abstract

Technological advances have led to greater use of both structural and functional brain imaging to assist with the diagnosis of dementia for the increasing numbers of people with cognitive decline as they age. In current clinical practice, structural imaging (CT or MRI) is used to identify space-occupying lesions and stroke. Functional methods, such as PET scanning of glucose metabolism, could be used to differentiate Alzheimer's disease from frontotemporal dementia, which helps to guide clinicians in symptomatic treatment strategies. New neuroimaging methods that are currently being developed can measure specific neurotransmitter systems, amyloid plaque and tau tangle concentrations, and neuronal integrity and connectivity. Successful co-development of neuroimaging surrogate markers and preventive treatments might eventually lead to so-called brain-check scans for determining risk of cognitive decline, so that physicians can administer disease-modifying medications, vaccines, or other interventions to avoid future cognitive losses and to delay onset of disease.

References

Aug 22, 2001·Lancet·A CagninR B Banati
Nov 22, 2001·JAMA : the Journal of the American Medical Association·D H SilvermanM E Phelps
Jan 16, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Kooresh Shoghi-JadidJorge R Barrio
Jun 22, 2002·BMJ : British Medical Journal·Gary W Small
Mar 4, 2003·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Larry TuneJohn M Hoffman
Jun 13, 2003·Radiology·Pamela M McMahonG Scott Gazelle
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Russell Katz
Apr 15, 2005·The New England Journal of Medicine·Ronald C PetersenUNKNOWN Alzheimer's Disease Cooperative Study Group
Oct 22, 2005·Lancet Neurology·David NearyDavid Mann
Mar 1, 2006·Neurology·I J DearyJ M Wardlaw
May 30, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Gary W SmallMichael E Phelps
Sep 27, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Emma J BurtonJohn T O'Brien
Feb 9, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Tilo T KircherDirk T Leube
May 25, 2007·Brain : a Journal of Neurology·John M RingmanGeorge Bartzokis

❮ Previous
Next ❯

Citations

Nov 13, 2009·Neuropsychology Review·Karen M RodrigueDenise C Park
Jan 29, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Maria Carmela TartagliaBruce L Miller
Feb 9, 2010·Nature Reviews. Neurology·Agneta NordbergBengt Långström
Feb 10, 2011·Nature Reviews. Neurology·Christiane ReitzRichard Mayeux
Jun 12, 2009·Brain : a Journal of Neurology·J L WoodardS M Rao
Dec 9, 2009·Nuclear Medicine Communications·Kun-Lin XiongWei-Guo Zhang
Sep 1, 2011·Rinshō shinkeigaku = Clinical neurology·Shinsuke FujiokaZbigniew K Wszolek
Aug 12, 2008·International Journal of Biological Sciences·Kun ZouHiroto Komano
Nov 1, 2009·Expert Opinion on Medical Diagnostics·Nobuyuki OkamuraVictor L Villemagne
Jan 31, 2012·Neuroimaging Clinics of North America·Meike W Vernooij, Marion Smits
Dec 15, 2010·Pediatric Neurology·Ajay Kumar, Harry T Chugani
May 30, 2009·International Journal of Law and Psychiatry·Pietro Pietrini, Valentina Bambini
Jun 3, 2008·Seminars in Nuclear Medicine·Daniel H S SilvermanGary W Small
Nov 29, 2015·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Gary W Small, Susan Greenfield
Nov 4, 2015·Frontiers in Neuroscience·Philip P Foster
Dec 5, 2008·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Ki-Dong EomHee-Myung Park
Jul 15, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Katell MevelGaël Chételat
Dec 18, 2013·Diabetes/metabolism Research and Reviews·Tali Cukierman-Yaffe
Apr 27, 2010·Annals of the New York Academy of Sciences·Diana W ShinemanHoward M Fillit
Jun 8, 2012·Geriatrics & Gerontology International·Takehiko DoiTakao Suzuki
Jun 5, 2010·Brain Pathology·Min ShiJing Zhang
Dec 3, 2014·Biological Psychiatry·Jonathan McConathy, Yvette I Sheline
Nov 1, 2011·NeuroImage·Kai-kai ShenUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 1, 2008·Expert Opinion on Medical Diagnostics·Pritha DasGin S Malhi
Jul 15, 2015·Behavioural Neurology·Hellen Livia Drumond MarraMarco Antonio Marcolin
Oct 10, 2012·Journal of the Neurological Sciences·Wolf-Dieter Heiss, Sibilla Zimmermann-Meinzingen
Nov 18, 2014·Frontiers in Neuroscience·Paul A AdlardGary F Egan
Oct 18, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Gary W Small
Nov 4, 2016·BMC Medicine·Wolf-Dieter HeissJacques de Reuck
Aug 11, 2011·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Leonardo BaldaçaraAndrea Parolin Jackowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Early Markers

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive and behavioral decline. Targeting markers in the earliest stages of the disease may mitigate the progression of AD. This feed focuses on early diagnosis and markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

© 2021 Meta ULC. All rights reserved