Current and novel therapeutic opportunities for systemic therapy in biliary cancer.

British Journal of Cancer
José J G Marinworking group 6 of the COST-action 18122 (Euro-Cholangio-NET) as part of the European Network for the study of Cholangiocarc

Abstract

Biliary tract cancers (BTCs) are a group of rare and aggressive malignancies that arise in the biliary tree within and outside the liver. Beyond surgical resection, which is beneficial for only a small proportion of patients, current strategies for treating patients with BTCs include chemotherapy, as a single agent or combination regimens, in the adjuvant and palliative setting. Increased characterisation of the molecular landscape of these tumours has facilitated the identification of molecular vulnerabilities, such as IDH mutations and FGFR fusions, that can be exploited for the treatment of BTC patients. Beyond targeted therapies, active research avenues explore the development of novel therapeutics that target the crosstalk between cancer and stroma, the cellular pathways involved in the regulation of cell death, the chemoresistance phenotype and the dysregulation of RNA. In this review, we discuss the therapeutic opportunities currently available in the management of BTC patients, and explore the strategies that can support the implementation of precision oncology in BTCs, including novel molecular targets, liquid biopsies and patient-derived predictive tools.

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Citations

Feb 17, 2021·Cancer Treatment and Research Communications·Alessandro Rizzo, Giovanni Brandi
Feb 25, 2021·Expert Opinion on Investigational Drugs·Massimiliano CadamuroLuca Fabris
Feb 23, 2021·Journal of Hepatology·Raffaella Casolino, Chiara Braconi
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Jul 27, 2021·International Journal of Cancer. Journal International Du Cancer·Xinni ChenJianjun Zou
Sep 14, 2021·The Cochrane Database of Systematic Reviews·Vor LuviraPorjai Pattanittum

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Methods Mentioned

BETA
surgical resection
biopsy
biopsies
xenografts

Clinical Trials Mentioned

NCT02170090
NCT03043547
NCT04005339
NCT03521219
NCT03427242
NCT02520141
NCT03377179
NCT03185988
NCT04209465
NCT03833661

Software Mentioned

ClarIDHy
PREDICT

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