Current and Perspective Diagnostic Techniques for COVID-19

ACS Infectious Diseases
Xi YuanPeiwu Qin

Abstract

Since late December 2019, the coronavirus pandemic (COVID-19; previously known as 2019-nCoV) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been surging rapidly around the world. With more than 1,700,000 confirmed cases, the world faces an unprecedented economic, social, and health impact. The early, rapid, sensitive, and accurate diagnosis of viral infection provides rapid responses for public health surveillance, prevention, and control of contagious diffusion. More than 30% of the confirmed cases are asymptomatic, and the high false-negative rate (FNR) of a single assay requires the development of novel diagnostic techniques, combinative approaches, sampling from different locations, and consecutive detection. The recurrence of discharged patients indicates the need for long-term monitoring and tracking. Diagnostic and therapeutic methods are evolving with a deeper understanding of virus pathology and the potential for relapse. In this Review, a comprehensive summary and comparison of different SARS-CoV-2 diagnostic methods are provided for researchers and clinicians to develop appropriate strategies for the timely and effective detection of SARS-CoV-2. The survey of current biosensors and dia...Continue Reading

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Datasets Mentioned

BETA
MN908947

Methods Mentioned

BETA
electron microscopy
bronchoalveolar lavage
biosensor
genosensor
chemical treatment
fluorescence resonance
nucleic acid capture
single-cell sequencing
Reverse Transcription-Polymerase Chain
PCR

Software Mentioned

SegNet
UNet
Net
DeepLabv3
Moderna
ID NOW
FCN
Inception
Keras
CanSino

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