Current and potential future role of PSMA-PET in patients with castration-resistant prostate cancer.

World Journal of Urology
Christian Daniel FankhauserIrene A Burger

Abstract

To review the current literature and discuss potential future roles of the novel positron emission tomography (PET) tracers targeting the prostate-specific membrane antigen (PSMA) in patients with castration-resistant prostate cancer (CRPC). A literature search on February 19th 2018 was conducted using the Medline database and www.clinicaltrials.gov . Additionally, illustrative cases of CRPC patients from our own institution who were restaged and treated based on PSMA-PET scan results are provided. 11 Studies met the inclusion criteria. PSMA-PET detected more metastatic lesions compared to conventional bone scan. Several patients were up-staged from non-metastatic CRPC (nmCRPC) to metastatic CRPC (mCRPC). Currently, no clear consensus exists regarding treatment response assessment in PSMA-PET scans for mCRPC patients undergoing treatment. Also, the role of PSMA-PET as a gatekeeper for systemic therapy or radioligands is currently undefined. PSMA-guided metastasis-directed radiotherapy may not only alleviate local symptoms but has the potential to defer systemic treatment in patients with oligoprogressive CRPC. Compared to bone scan, PSMA-PET is more sensitive and specific to detect metastases but the therapeutic consequences of...Continue Reading

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Mar 6, 2019·Current Oncology Reports·Clayton P SmithBaris Turkbey
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Jun 30, 2021·Annals of Nuclear Medicine·Saskia FassbindBenedikt Kranzbühler

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