Current antimicrobial usage for the management of infections in leukemic patients in Japan: results of a survey

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Minoru Yoshida, Ryuzo Ohno

Abstract

We report the findings of a questionnaire distributed by the Committee of Supportive Care of the Japan Adult Leukemia Study Group to 196 hospitals throughout Japan. For antimicrobial prophylaxis, the oral quinolones are prescribed by 38% of physicians and polymixin B by 31%. For antifungal prophylaxis, amphotericin B is prescribed by 42% of physicians and fluconazole by 41%. Febrile neutropenia is empirically treated with cephalosporin or carbapenem monotherapy by 35% of physicians. Overall, dual therapy (i.e., an aminoglycoside plus a cephalosporin, a carbapenem, or an antipseudomonal penicillin) is prescribed by 50% of physicians. When response to initial empirical therapy does not occur after 3-4 days, 51% of physicians add an antifungal agent; fluconazole is preferred to amphotericin B (prescribed by 66% vs. 28% of physicians). For the treatment of fungemia due to Candida albicans, fluconazole was prescribed by 59% of physicians in cases of stable disease and amphotericin B was prescribed by 57% of physicians in cases of unstable disease. Amphotericin B is selected to treat invasive aspergillosis, but a dose of 0.5-0.7 mg/kg, inadequate for this disease, is prescribed by 44% of physicians. Granulocyte colony-stimulating fac...Continue Reading

References

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Citations

Aug 1, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T LehrnbecherD Schwabe
Dec 7, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T SaitoS Ichiyama
Jul 14, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juan J Picazo
Jul 9, 2013·Critical Care Clinics·Eric J Bow
Jul 1, 2011·The Korean Journal of Internal Medicine·Dong-Gun LeeJung-Hyun Choi
Jun 7, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Shun-Ichi KimuraUNKNOWN Japan Adult Leukemia Study Group (JALSG)
Jun 4, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Hideaki KatoUNKNOWN Japan Adult Leukemia Study Group

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