Current approaches for avoiding the limitations of circulating tumor cells detection methods-implications for diagnosis and treatment of patients with solid tumors

Translational Research : the Journal of Laboratory and Clinical Medicine
Artur KowalikStanisław Góźdź

Abstract

Eight million people die of cancer each year and 90% of deaths are caused by systemic disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus are the subject of extensive research and an abiding interest to biotechnology and pharmaceutical companies. Recent technological advances have resulted in greatly improved CTC detection, enumeration, expansion, and culture methods. However, despite the fact that nearly 150 years have passed since the first detection and description of CTCs in human blood and enormous technological progress that has taken place in this field, especially within the last decade, few CTC detection methods have been approved for routine clinical use. This reflects the substantial methodological problems related to the nature of these cells, their heterogeneity, and diverse metastatic potential. Here, we provide an overview of CTC phenotypes, including the plasticity of CTCs and the relevance of inflammation and cell fusion phenomena for CTC biology. We also review the literature on CTC detection methodology-its recent improvements, clinical significance, and efforts of its clinical application in cancer patients management. At present, CTC detection remains a challenging dia...Continue Reading

References

May 10, 2013·PloS One·Frank A W CoumansLeon W M M Terstappen

❮ Previous
Next ❯

Citations

Feb 6, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Marius IlieUNKNOWN STALKLUNG01 and AIR Study Consortium Investigators
Dec 6, 2017·Expert Review of Anticancer Therapy·Anthony LopezJaffer A Ajani
Jan 24, 2019·Clinical Genetics·Sahar AlimirzaieMohammad R Akbari
Apr 17, 2019·Cancer Biology & Therapy·Anatoli KustanovichAlbert Grinshpun
Dec 13, 2019·Cellular Oncology (Dordrecht)·Meysam YousefiSeyed H Ghaffari
Oct 15, 2019·Expert Review of Molecular Diagnostics·Erik KoubaLiang Cheng
Jun 22, 2018·Oncotarget·Dipesh Kumar YadavTingbo Liang
Apr 7, 2020·Journal of Clinical Laboratory Analysis·Cheng AnXixiong Kang
Sep 21, 2018·Molecular and Clinical Oncology·Marco DanovaGiuliano Mazzini
Aug 9, 2020·Frontiers in Molecular Biosciences·Ekaterina IvanovaDerek John Richard
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Theresa D AhrensMette Ø Agerbæk
Apr 11, 2018·Frontiers in Medicine·Charlotte K Y NgSalvatore Piscuoglio
Mar 31, 2018·The Cancer Journal·Ashutosh AgarwalRichard J Cote
Feb 1, 2018·Nature Biomedical Engineering·Mahla PoudinehShana O Kelley
May 12, 2020·Frontiers in Molecular Biosciences·Sugandha BhatiaErik W Thompson
Apr 25, 2019·Nature Biomedical Engineering·Tae-Hyun Shin, Jinwoo Cheon
Mar 21, 2019·Frontiers in Oncology·Jatta SaarenheimoAntti Jekunen
Sep 27, 2018·Scientific Reports·Miranda E Sowder, Rachelle W Johnson
Sep 3, 2019·Frontiers in Oncology·Ewelina StelcerWiktoria Maria Suchorska
Aug 28, 2020·International Journal of Molecular Sciences·Deborah RotoliSilvia Catuogno
Aug 23, 2020·Cancers·Ruchi Agashe, Razelle Kurzrock
Dec 5, 2019·Scientific Reports·Masaya HattoriHiroji Iwata
Nov 27, 2020·Journal of Immunological Methods·Kathryn E YohVicki Plaks
Dec 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fatemeh Farshchi, Mohammad Hasanzadeh
Dec 12, 2020·Computational and Structural Biotechnology Journal·Wu-Hu ZhangLiang Liu
Nov 17, 2020·Frontiers in Immunology·Antonella SistiguRuggero De Maria
Nov 2, 2019·Hematology/oncology Clinics of North America·Bo SunAndrew Z Wang
Jun 3, 2021·Cancers·Nuria Carmona-UleAna Belén Dávila-Ibáñez
Jul 13, 2021·JCO Precision Oncology·Clinton YamTimothy A Yap
Jul 31, 2021·Expert Review of Molecular Diagnostics·Evagelia ChantzaraAthanasios Kotsakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Annals of Oncology : Official Journal of the European Society for Medical Oncology
L KhojaA Fusi
Annals of Oncology : Official Journal of the European Society for Medical Oncology
P GazzanigaL Frati
© 2022 Meta ULC. All rights reserved