Current approaches in retrieval and heart preservation

Annals of Cardiothoracic Surgery
Maria Monteagudo VelaAndre Simon

Abstract

Fifty years after the first successful heart transplantation, despite multiple advances in the treatment of advanced acute and chronic heart failure, there is still no equivalent to heart transplantation as a long-term treatment for end-stage heart failure. Transplantation is, however, limited by the scarcity and quality of heart allografts. Donors are nowadays significantly older, particularly in European countries, and traumatic head injury as the cause of death has been replaced by intracerebral hemorrhage or hypoxic brain damage in the majority of cases. In addition, many donors have undergone extensive resuscitation efforts. Recipient characteristics have progressively changed too within the last couple of decades; recipients are older, often with comorbidities and nearly half of them are bridged to transplant with a wide variety of mechanical circulatory support devices. These developments have resulted in heart transplant surgery becoming significantly more challenging with longer more complex surgery and increased ischemia times for organs that were previously considered to be borderline or non-transplantable in many cases. To address this, several options have been explored within the last years and as a result, novel ...Continue Reading

Citations

Feb 24, 2019·Annual Review of Biomedical Engineering·Eleonora Dal SassoLaura Iop
Aug 7, 2020·Clinical Transplantation·Antonella GaleonePascal Leprince
May 26, 2018·AIDS·Michael A Kolber
Aug 28, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jennifer S McLeodGabe E Owens
Mar 21, 2019·Experimental Biology and Medicine·Meghan Pinezich, Gordana Vunjak-Novakovic
Aug 31, 2019·Journal of the American Heart Association·Yaron D BaracCarmelo A Milano
Jun 10, 2018·Pediatric Transplantation·Richard Kirk, Anne I Dipchand
Sep 14, 2020·The Annals of Thoracic Surgery·Yaron D BaracCarmelo A Milano
May 1, 2021·Journal of Cardiovascular Development and Disease·Luciana Da Silveira Cavalcante, Shannon N Tessier
May 7, 2021·Journal of Materials Science. Materials in Medicine·Brian KatoFinosh G Thankam
Nov 20, 2020·Transplantation·Laura Anguela-CalvetEva Oliver-Juan

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