Current approaches to osteoporosis treatment

Current Opinion in Rheumatology
Sian Yik Lim, Marcy B Bolster

Abstract

Osteoporosis is a skeletal disorder in which bone strength is decreased leading to an increased risk of fracture. In line with advances in knowledge of bone biology, the past several years have held major therapeutic advances in osteoporosis treatment. In this article, we review the current approaches to osteoporosis treatment with a focus on issues of interest to the practicing rheumatologist. In addition to the bisphosphonates, the introduction of denosumab, teriparatide and selective oestrogen-receptor modulators, as well as the development of new therapeutic agents (romosozumab and odanacatib) has opened the door to new approaches, including individualization of treatment in different clinical circumstances based on patient comorbidities and preference; combination therapy to optimize treatment effect; and consideration of goal-based treatment. Postmarketing surveillance of bisphosphonates has revealed several safety concerns including osteonecrosis of the jaw and atypical femoral fractures. Bisphosphonate drug holidays should be considered in patients on bisphosphonate therapy because prolonged treatment may be associated with adverse events. Substantial progress has been made in the past several years in the understanding...Continue Reading

References

Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·D M BlackUNKNOWN Fracture Intervention Trial
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Sep 23, 2003·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Jul 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Charles H ChesnutUNKNOWN Oral Ibandronate Osteoporosis Vertebral Fracture Trial in North America and Europe (BONE)
Aug 12, 2005·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
May 26, 2006·The New England Journal of Medicine·Ego Seeman, Pierre D Delmas
Dec 28, 2006·JAMA : the Journal of the American Medical Association·Dennis M BlackUNKNOWN FLEX Research Group
May 4, 2007·The New England Journal of Medicine·Dennis M BlackUNKNOWN HORIZON Pivotal Fracture Trial
Jul 20, 2007·Arthritis Research & Therapy·Brendan F Boyce, Lianping Xing
Sep 20, 2007·The New England Journal of Medicine·Kenneth W LylesUNKNOWN HORIZON Recurrent Fracture Trial
Jul 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cathleen S Colón-EmericJay Magaziner
Aug 13, 2009·The New England Journal of Medicine·Steven R CummingsUNKNOWN FREEDOM Trial
Nov 6, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L A BeaupreS R Majumdar
Apr 15, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sophie A JamalPaul D Miller
May 6, 2011·The New England Journal of Medicine·Jörg SchilcherPer Aspenberg
Dec 14, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dennis M BlackRichard Eastell
Jul 28, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Richard M DellSusan M Ott
Nov 28, 2012·The American Journal of Medicine·Michael McClungE Michael Lewiecki
Jan 3, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Felicia CosmanJohn H Krege
Jan 10, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven R CummingsE Michael Lewiecki
Apr 26, 2013·Expert Opinion on Drug Safety·Jean-Yves ReginsterOlivier Bruyère
May 29, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth ShaneMichael P Whyte
Jun 12, 2013·Calcified Tissue International·Maurizio RossiniSilvano Adami
Jul 11, 2013·Rheumatology·Ernest SureshBo Abrahamsen
Jul 17, 2013·Therapeutic Advances in Musculoskeletal Disease·Dima L Diab, Nelson B Watts
Nov 1, 2013·Acta Orthopaedica·Efstathios DrampalosIoannis Michos
Dec 18, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S-H LeeC-C Lee
Jan 3, 2014·The New England Journal of Medicine·Michael R McClungHenry G Bone
Apr 2, 2014·Therapeutic Advances in Musculoskeletal Disease·E Michael Lewiecki
Apr 10, 2014·The Journal of Clinical Endocrinology and Metabolism·Michael Pazianas, Roger Smith
May 7, 2014·JAMA Internal Medicine·Douglas C BauerDennis M Black
Jul 30, 2014·Reumatismo·N MaruottiF P Cantatore
Aug 31, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Osa EmohareElie Gertner
Sep 10, 2014·Annals of Internal Medicine·Carolyn J CrandallPaul G Shekelle
Sep 23, 2014·Current Rheumatology Reports·Juliet Aizer, Marcy B Bolster
Nov 30, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·J Y ReginsterO Bruyere

❮ Previous
Next ❯

Citations

Mar 8, 2016·International Journal of Surgery Case Reports·Mayumi YaoAkira Sasaki
Sep 7, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Jordi BoverJosé Ballarín
Feb 9, 2017·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ozra Tabatabaei-MalazyBagher Larijani
Jun 16, 2017·The American Journal of Pathology·Thaqif El KhassawnaChristian Heiss
Mar 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Negar GolchinShelly L Gray
Jun 30, 2019·International Journal of Molecular Sciences·Zuha ImtiyazMei-Hsien Lee
May 11, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E T NguyenS Y Lim
Feb 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nur-Vaizura MohamadKok-Yong Chin

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Rheumatic Diseases Clinics of North America
Jie ZhangJeffrey R Curtis
Journal of Endocrinological Investigation
S IshtiaqG Hampson
Therapeutic Advances in Drug Safety
Cora McGreevy, David Williams
Menopause : the Journal of the North American Menopause Society
Dima L Diab, Nelson B Watts
© 2021 Meta ULC. All rights reserved