Abstract
Inhaled administration is underutilised because the drug discovery process is viewed as challenging, risky, and expensive. However, unmet medical need continues to grow, and significant opportunities exist to discover novel inhaled medicines delivering the required lung concentrations while minimising systemic exposure. This profile could be achieved by a combination of properties, including lung retention and low oral bioavailability. Property-based rules exist for orally administered compounds, but there has been limited progress defining in silico predictors to guide the discovery of novel inhaled drugs. Recently, the use of informative cell- and tissue-based screens has greatly facilitated the identification of compounds with optimal characteristics for inhaled delivery. Here, we address opportunities for novel inhaled drugs, and the key challenges and uncertainties hampering progress.
Citations
May 18, 2019·Drug Development and Industrial Pharmacy·Edit BenkeRita Ambrus
Apr 4, 2019·The Journal of Pharmacology and Experimental Therapeutics·Malcolm BeggEdith M Hessel
Aug 31, 2018·Journal of the Royal Society, Interface·Hannah DonnellyMatthew J Dalby
Oct 16, 2019·Current Pharmaceutical Biotechnology·Haofan LiuLiandong Hu
Aug 31, 2020·The AAPS Journal·Nicola MelilloPaolo Magni
Mar 7, 2019·Frontiers in Pharmacology·Kent MinerJohn K Sullivan
Aug 12, 2020·Drug Development Research·Cristiano Colalto
Dec 17, 2020·Chemical Society Reviews·Sabine SzuneritsRabah Boukherroub
Dec 20, 2020·Pharmacology Research & Perspectives·Lindsey CassGarth Rapeport
Nov 21, 2020·The Journal of Infectious Diseases·John DeVincenzoGarth Rapeport
Feb 2, 2021·PloS One·Matthew S CoatesKazuhiro Ito
Nov 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Thomas E J ChavasPatrick S Stayton
Dec 23, 2020·Journal of Fungi·Alison MurrayPete Strong
Apr 26, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Astrid BaclePascal Le Corre
May 7, 2021·Journal of Immunotoxicology·Leonor de BragancaJeremy P Derrick
May 21, 2021·Annals of Thoracic Medicine·Adel S AlharbiMuslim M Alsaadi
Aug 1, 2021·Advanced Drug Delivery Reviews·Arbel Artzy-SchnirmanJosué Sznitman
Mar 19, 2020·ACS Medicinal Chemistry Letters·Aimie E GarcesMichael J Stocks
Sep 22, 2021·Drug Discovery Today·Elisa PasquaChris Hurley