Current best practice in the management of neuroendocrine tumors

Therapeutic Advances in Endocrinology and Metabolism
Marina TsoliGregory Kaltsas

Abstract

Neuroendocrine neoplasms are rare tumors that display marked heterogeneity with varying natural history, biological behavior, response to therapy and prognosis. Their management is complex, particularly as a number of them may be associated with a secretory syndrome and involve a variety of options. A number of factors such as proliferation rate, degree of differentiation, functionality and extent of the disease are mostly utilized to tailor treatment accordingly, ideally in the context of a multidisciplinary team. In addition, a number of relevant scientific societies have published therapeutic guidelines in an attempt to direct and promote evidence-based treatment. Surgery remains the treatment of choice with an intention to cure while it may also be recommended in some cases of metastatic disease and difficult to control secretory syndromes. Long-acting somatostatin analogs constitute the main treatment for the majority of functioning tumors, whereas specific evolving agents such as telotristat may be used for the control of carcinoid syndrome and related sequelae. In patients with advanced disease not amenable to surgical resection, treatment options include locoregional therapies, long-acting somatostatin analogs, molecula...Continue Reading

References

Jan 1, 1990·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·G StamatisD Greschuchna
Jun 1, 1985·American Journal of Surgery·J M Rosenberg, J P Welch
Jul 11, 1998·Journal of the American College of Surgeons·H ChenM A Choti
Apr 11, 2000·Journal of the American College of Surgeons·R S ChamberlainL H Blumgart
Nov 30, 2000·The American Journal of Gastroenterology·M DucreuxP Rougier
May 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T AparicioP Rougier
Nov 8, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P F QuaedvliegB G Taal
Mar 16, 2002·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mi-Young JeungCatherine Roy
Sep 18, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Wilson M ClementsAndrew M Lowy
May 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ObergB Wiedenmann
Jun 8, 2004·Endocrine Reviews·Gregory A KaltsasAshley B Grossman
Sep 16, 2004·Heart·David J Fox, Rajdeep S Khattar
Oct 13, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K Oberg
Nov 2, 2004·World Journal of Surgery·Henning DralleOliver Gimm
Dec 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria A KouvarakiJames C Yao
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·K Martin HoffmannRobert T Jensen
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·Jeffrey A Norton
Nov 16, 2005·Circulation·Jacob E MøllerHeidi M Connolly
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Göran Akerström, Per Hellman
Oct 18, 2007·Neuroendocrinology·Hakan AhlmanUNKNOWN Frascati Consensus Conference participants
Jan 8, 2008·The Lancet Oncology·Irvin M ModlinAnders Sundin
Jan 23, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R BettiniM Falconi
May 14, 2008·Cancer·Bjorn I GustafssonIrvin M Modlin
Jun 3, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T R HalfdanarsonG M Petersen
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoDouglas B Evans
Jul 30, 2008·European Journal of Endocrinology·Simona Grozinsky-GlasbergDavid J Gross
Dec 17, 2008·Neuroendocrinology·Kjell ObergUNKNOWN European Neuroendocrine Tumor Society
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catharina M KorseJohannes M G Bonfrer
Dec 10, 2009·Endocrine-related Cancer·Dik J KwekkeboomEric P Krenning
Jan 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tina BinderupAndreas Kjaer
Apr 28, 2010·Virchows Archiv : an International Journal of Pathology·Günter KlöppelDavid S Klimstra
Sep 9, 2010·The American Journal of Gastroenterology·Libby EllisMichel P Coleman
Nov 6, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Phillip G ClaringboldJ Harvey Turner
Dec 8, 2010·Scandinavian Journal of Gastroenterology·Constantin S JianuHelge L Waldum
Jan 13, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Thomas C KweeAbass Alavi
Feb 5, 2011·Journal of Surgical Oncology·John T Mullen, Diane M F Savarese
Feb 11, 2011·The New England Journal of Medicine·Eric RaymondPhilippe Ruszniewski
May 11, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anna ImhofMartin A Walter

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Citations

Feb 29, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Marina TsoliGregory Kaltsas
Feb 25, 2020·International Journal of Endocrinology·Karin MayerGeorg Feldmann
Oct 17, 2019·World Journal of Clinical Cases·Anna MrzljakDanko Mikulic
Sep 20, 2020·Journal of Clinical Medicine·Regis SoucheSebastien Gaujoux
Mar 1, 2021·Current Treatment Options in Oncology·Chiara BorgaMatteo Fassan
Apr 3, 2021·World Journal of Gastrointestinal Surgery·Cornelius J FernandezJoseph M Pappachan
Sep 3, 2021·Cancer Immunology, Immunotherapy : CII·Christo KoleDimitrios Schizas

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Methods Mentioned

BETA
surgical resection
dissection
imaging techniques
pancreatectomy
X-ray

Software Mentioned

CLARINET

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