Current Cell-Based Strategies for Whole Kidney Regeneration

Tissue Engineering. Part B, Reviews
Nafiseh PoornejadAlonzo D Cook

Abstract

Chronic kidney diseases affect thousands of people worldwide. Although hemodialysis alleviates the situation by filtering the patient's blood, it does not replace other kidney functions such as hormone release or homeostasis regulation. Consequently, orthotopic transplantation of donor organs is the ultimate treatment for patients suffering from end-stage renal failure. Unfortunately, the number of patients on the waiting list far exceeds the number of donors. In addition, recipients must remain on immunosuppressive medications for the remainder of their lives, which increases the risk of morbidity due to their weakened immune system. Despite recent advancements in whole organ transplantation, 40% of recipients will face rejection of implanted organs with a life expectancy of only 10 years. Bioengineered patient-specific kidneys could be an inexhaustible source of healthy kidneys without the risk of immune rejection. The purpose of this article is to review the pros and cons of several bioengineering strategies used in recent years and their unresolved issues. These strategies include repopulation of natural scaffolds with a patient's cells, de-novo generation of kidneys using patient-induced pluripotent stem cells combined wit...Continue Reading

References

Jul 2, 1998·Kidney International·S A RogersM R Hammerman
Nov 6, 1998·Science·J A ThomsonJ M Jones
Feb 28, 2001·The New England Journal of Medicine·T Shin'okaY Ikada
Feb 19, 2002·Kidney International·Qais Al-Awqati, Juan A Oliver
Dec 24, 2002·Nature Medicine·Benjamin DekelYair Reisner
May 26, 2004·Transplant Immunology·Stephen F Badylak
Sep 1, 1960·Proceedings of the National Academy of Sciences of the United States of America·P Weiss, A C Taylor
Apr 25, 2006·Lancet·Anthony AtalaAlan B Retik
Dec 13, 2006·Progress in Molecular and Subcellular Biology·M Little
Feb 8, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jeannette NussbaumCharles E Murry
Oct 5, 2007·The New England Journal of Medicine·Nicolas L'HeureuxLuis M de la Fuente
Dec 18, 2007·Seminars in Immunology·Stephen F Badylak, Thomas W Gilbert
Oct 22, 2008·Acta Biomaterialia·Stephen F BadylakThomas W Gilbert
Mar 21, 2009·Blood·Yuin-Han LohGeorge Q Daley
Sep 5, 2009·Journal of the American Society of Nephrology : JASN·Edward A RossChristopher D Batich
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ning SunJoseph C Wu
Feb 17, 2010·Tissue Engineering. Part a·Karina H NakayamaAlice F Tarantal
Jul 16, 2010·Nature Medicine·Harald C OttJoseph P Vacanti
Jul 21, 2010·Nature·K KimG Q Daley
Feb 8, 2011·Biomaterials·Peter M CrapoStephen F Badylak
Mar 23, 2011·Annual Review of Biomedical Engineering·Stephen F BadylakKorkut Uygun
Apr 9, 2011·Nature·Mototsugu EirakuYoshiki Sasai
Apr 28, 2011·Proceedings of the National Academy of Sciences of the United States of America·Janghwan KimSheng Ding
May 14, 2011·Journal of the American Society of Nephrology : JASN·Bi SongSharon D Ricardo
May 17, 2011·Nature·Tongbiao ZhaoYang Xu
May 24, 2011·International Journal of Nephrology·Takashi YokooShinya Yokote
Jun 4, 2011·Journal of the American Society of Nephrology : JASN·Ting ZhouMiguel A Esteban
Jul 5, 2011·Acta Biomaterialia·Rémi Parenteau-BareilFrançois Berthod
Jan 3, 2012·Biochemical and Biophysical Research Communications·Masaki NishikawaNorimoto Yanagawa
Mar 27, 2012·Cell Stem Cell·Dong Wook HanHans R Schöler
Mar 27, 2012·Cell Stem Cell·Marc ThierFrank Edenhofer
May 9, 2012·Transplantation Proceedings·K M Park, H M Woo
Jun 19, 2012·Cell Stem Cell·Tokushige NakanoYoshiki Sasai

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Citations

Oct 17, 2017·Advanced Healthcare Materials·Samad AhadianMilica Radisic
Nov 5, 2019·Scientific Reports·Junmei WanMaik Hüttemann
Feb 6, 2020·The International Journal of Biochemistry & Cell Biology·Hasini A KalpageMaik Hüttemann

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BETA
biopsies
bioprinting

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