Current Challenges Facing the Translation of Brain Computer Interfaces from Preclinical Trials to Use in Human Patients

Frontiers in Cellular Neuroscience
Maxwell D MurphyRandolph J Nudo

Abstract

Current research in brain computer interface (BCI) technology is advancing beyond preclinical studies, with trials beginning in human patients. To date, these trials have been carried out with several different types of recording interfaces. The success of these devices has varied widely, but different factors such as the level of invasiveness, timescale of recorded information, and ability to maintain stable functionality of the device over a long period of time all must be considered in addition to accuracy in decoding intent when assessing the most practical type of device moving forward. Here, we discuss various approaches to BCIs, distinguishing between devices focusing on control of operations extrinsic to the subject (e.g., prosthetic limbs, computer cursors) and those focusing on control of operations intrinsic to the brain (e.g., using stimulation or external feedback), including closed-loop or adaptive devices. In this discussion, we consider the current challenges facing the translation of various types of BCI technology to eventual human application.

References

Jan 1, 1975·Electroencephalography and Clinical Neurophysiology·G Pfurtscheller, R Cooper
Mar 1, 1991·Electroencephalography and Clinical Neurophysiology·J R WolpawC A Forneris
Feb 1, 1985·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J T MurphyY C Wong
Sep 26, 1986·Science·A P GeorgopoulosR E Kettner
Feb 28, 1969·Science·E E Fetz
Jul 10, 1983·The Journal of Comparative Neurology·J P Donoghue, C Parham
Apr 18, 1998·Electroencephalography and Clinical Neurophysiology·G PfurtschellerM Pregenzer
Apr 3, 1999·IEEE Transactions on Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·P J Rousche, R A Normann
Apr 7, 1999·Nature·N BirbaumerH Flor
Jun 8, 2002·Science·Dawn M TaylorAndrew B Schwartz
Feb 1, 1965·Electroencephalography and Clinical Neurophysiology·R COOPERW G WALTER
Nov 19, 2003·PLoS Biology·Jose M CarmenaMiguel A L Nicolelis
May 15, 2004·Cerebral Cortex·Eugene M IzhikevichGerald M Edelman
Jun 11, 2004·IEEE Transactions on Bio-medical Engineering·Benjamin BlankertzNiels Birbaumer
Sep 8, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christoph M MichelRolando Grave de Peralta
Dec 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jonathan R Wolpaw, Dennis J McFarland
May 7, 2005·Journal of Neural Engineering·Eric C LeuthardtDaniel W Moran
Jun 24, 2006·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·J Adam WilsonJustin C Williams
Jul 14, 2006·Nature·Leigh R HochbergJohn P Donoghue
Aug 24, 2006·Journal of Computational Neuroscience·Antonio Pazienti, Sonja Grün
Oct 24, 2006·Nature·Andrew JacksonEberhard E Fetz
Feb 3, 2007·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·W WuM J Black
Jun 22, 2007·Journal of Neuroscience Methods·Justin C SanchezJose C Principe
Sep 18, 2007·Journal of Neural Engineering·G SchalkJ R Wolpaw
Nov 21, 2007·Journal of Neuroscience Methods·Tobias PistohlCarsten Mehring
Dec 7, 2007·Journal of Neural Engineering·Justin C WilliamsDaryl R Kipke
Mar 4, 2008·Journal of Neural Engineering·G SchalkE C Leuthardt
Mar 20, 2008·Computational Intelligence and Neuroscience·Michael BenschNiels Birbaumer
May 30, 2008·Nature·Meel VellisteAndrew B Schwartz
Apr 8, 2009·Neural Networks : the Official Journal of the International Neural Network Society·John P CunninghamKrishna V Shenoy
Apr 8, 2009·NeuroImage·Takufumi YanagisawaToshiki Yoshimine
Jun 3, 2009·Brain Research·Matthew P WardPedro P Irazoqui
Jul 3, 2009·Neurosurgical Focus·Chandan G ReddyMatthew A Howard
Jul 3, 2009·Neurosurgical Focus·Eric C LeuthardtDaniel W Moran
Apr 22, 2010·Frontiers in Neuroengineering·Zenas C ChaoNaotaka Fujii
May 13, 2010·Journal of Neural Engineering·Dennis J McFarlandJonathan R Wolpaw
Oct 15, 2010·Journal of Neurophysiology·John P CunninghamKrishna V Shenoy
Feb 15, 2011·Journal of Neurosurgery·Takufumi YanagisawaToshiki Yoshimine
Mar 2, 2011·Biomedical Microdevices·Patrick T McCarthyMasaru P Rao
Apr 22, 2011·Journal of Neural Engineering·Marc W SlutzkyLee E Miller
Jun 17, 2011·Journal of Neural Engineering·Theodore W BergerSam A Deadwyler
Jul 15, 2011·Medical & Biological Engineering & Computing·Lana Popović ManeskiDejan B Popović

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Citations

Sep 30, 2016·The Journal of International Medical Research·Marta GandollaAlessandra Pedrocchi
Aug 15, 2019·Journal of Neurophysiology·Benjamin FischerDetlef Wegener
Dec 19, 2019·Frontiers in Neuroinformatics·Ksenia VolkovaAlexei Ossadtchi
Sep 22, 2017·Journal of Neural Engineering·L Specker Sullivan, J Illes
Jun 24, 2017·Science and Engineering Ethics·Laura Specker SullivanSara Goering
Dec 18, 2020·Frontiers in Neuroscience·Jonathan DelijorgeJavier M Antelis
Jan 22, 2021·Journal of Neural Engineering·Nur AhmadiChristos-Savvas Bouganis

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