Current challenges in pediatric heart transplantation for congenital heart disease

Current Opinion in Organ Transplantation
J K Kirklin

Abstract

Pediatric heart transplantation is an established therapy for end-stage cardiac disease without suitable medical or surgical options. However, transplantation for congenital heart disease carries an incremental risk that challenges the pediatric transplant team on multiple levels. With improved outcomes following palliative and corrective congenital cardiac surgery, cardiac transplantation has decreased in recent years as a primary therapy. Nevertheless, congenital heart disease remains the most common indication for cardiac transplantation during infancy. Primary transplantation in infancy is selectively recommended for severe systemic ventricular dysfunction, severe atrioventricular valve insufficiency, and occlusive coronary artery anomalies, particularly with single ventricle physiology. Wait-list mortality remains highest for infants with prior palliative surgery and patients with failing Fontan physiology, both of whom have limited options for effective mechanical circulatory support. The sensitized patient carries an increased risk with prolonged wait times, although virtual cross-matches and single bead assays for donor-specific antigens have facilitated the transplant process. Early and late survival after transplantat...Continue Reading

References

Dec 1, 1968·The American Journal of Cardiology·A KantrowitzH E Carstensen
Jul 19, 2006·Circulation·D BernsteinUNKNOWN Pediatric Heart Transplant Study
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Douglas MahChristopher S D Almond
Oct 19, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Clifford ChinDolly Tyan
Feb 4, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C S AlmondT P Singh
Feb 7, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Heather T HendersonKirk R Kanter
Feb 14, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Melanie D EverittUNKNOWN Pediatric Heart Transplant Study Investigators
Apr 17, 2012·The Journal of Thoracic and Cardiovascular Surgery·Ryan R DaviesJan M Quaegebeur
May 2, 2012·Current Cardiology Reviews·Avihu Z Gazit, Charles E Canter
May 2, 2012·Current Cardiology Reviews·Richard E Chinnock, Leonard L Bailey
May 2, 2012·Current Cardiology Reviews·Bassem N Mora, Charles B Huddleston
May 29, 2012·The Annals of Thoracic Surgery·Rochus K VoellerCharles B Huddleston
Nov 13, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Adriana ZeeviSteven Webber
Feb 6, 2013·The Journal of Thoracic and Cardiovascular Surgery·Prashanth VallabhajosyulaAlberto Pochettino
Feb 12, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Matthew J O'ConnorRobert E Shaddy
May 4, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Phil BothaMassimo Griselli
Jun 13, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Melisa OlivaChristopher S Almond
Nov 5, 2013·The Journal of Thoracic and Cardiovascular Surgery·Aamir JeewaAnne I Dipchand
Dec 25, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kathleen E SimpsonCharles E Canter
Feb 11, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ajay J IyengarIgor E Konstantinov
Apr 15, 2014·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Anees J Razzouk, Leonard L Bailey
May 16, 2014·The Journal of Thoracic and Cardiovascular Surgery·Byung Won YooSeung Up Kim
Jun 4, 2014·Circulation·Chesney CastleberryClifford Chin
Oct 4, 2014·The Journal of Thoracic and Cardiovascular Surgery·Robert J DabalYung Lau
Nov 13, 2014·Pediatric Transplantation·Seth A HollanderDaniel Bernstein
Dec 3, 2014·The Annals of Thoracic Surgery·Hannah CopelandLeonard Bailey

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Citations

Apr 11, 2018·Pediatric Transplantation·Michael O KillianKelli N Triplett
Jul 25, 2019·Current Opinion in Pediatrics·Laura D'AddeseElfriede Pahl
Oct 2, 2021·World Journal for Pediatric & Congenital Heart Surgery·Firat AltinShriprasad R Deshpande

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Methods Mentioned

BETA
biopsy
homograft

Software Mentioned

GoreTex

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