Current Challenges in Volatile Organic Compounds Analysis as Potential Biomarkers of Cancer

Journal of Biomarkers
Kamila Schmidt, Ian Podmore

Abstract

An early diagnosis and appropriate treatment are crucial in reducing mortality among people suffering from cancer. There is a lack of characteristic early clinical symptoms in most forms of cancer, which highlights the importance of investigating new methods for its early detection. One of the most promising methods is the analysis of volatile organic compounds (VOCs). VOCs are a diverse group of carbon-based chemicals that are present in exhaled breath and biofluids and may be collected from the headspace of these matrices. Different patterns of VOCs have been correlated with various diseases, cancer among them. Studies have also shown that cancer cells in vitro produce or consume specific VOCs that can serve as potential biomarkers that differentiate them from noncancerous cells. This review identifies the current challenges in the investigation of VOCs as potential cancer biomarkers, by the critical evaluation of available matrices for the in vivo and in vitro approaches in this field and by comparison of the main extraction and detection techniques that have been applied to date in this area of study. It also summarises complementary in vivo, ex vivo, and in vitro studies conducted to date in order to try to identify volati...Continue Reading

References

Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·L PaulingP Cary
Jun 1, 1994·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·R K PortenoyW Hoskins
Aug 1, 1994·Free Radical Biology & Medicine·C M KneepkensC C Roy
Jan 1, 1997·Free Radical Biology & Medicine·M YazdanpanahD C Lehotay
Oct 28, 1998·Environmental Health Perspectives·F J RomeroJ Romá
Jul 20, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·M PhillipsR N Cataneo
Apr 1, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·R HysplerV Balasová
Jul 20, 2000·Journal of Chromatographic Science·J Pawliszyn
Nov 20, 2001·Nature·C HagleitnerH Baltes
Nov 16, 2002·Analytical Chemistry·Heather LordJanusz Pawliszyn
Apr 3, 2003·Rapid Communications in Mass Spectrometry : RCM·David SmithAlicia El Haj
Jun 11, 2003·Chest·Michael PhillipsWilliam N Rom
Jun 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Takahiro Mitsui, Takaharu Kondo
Jul 2, 2003·Biosensors & Bioelectronics·Corrado Di NataleArnaldo D'Amico
May 20, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael PhillipsJoel Greenberg
Jul 16, 2004·Seminars in Radiation Oncology·Peter Vaupel
Jul 21, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chunhui DengNing Li
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael PhillipsMark J Zucker
Sep 25, 2004·BMJ : British Medical Journal·Carolyn M WillisJohn C T Church
Oct 21, 2004·Mass Spectrometry Reviews·David Smith, Patrik Spanel
Nov 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chunhui DengXiangmin Zhang
Sep 13, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hao YuPing Wang
Feb 4, 2006·The European Respiratory Journal·M BarkerR Koppmann
Feb 18, 2006·Integrative Cancer Therapies·Michael McCullochTeresa Janecki
Mar 4, 2006·Clinical Chemistry·Wenqing Cao, Yixiang Duan
Apr 26, 2006·Tuberculosis·Michael PhillipsOlaf Tietje
Feb 3, 2007·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Laert Oliveira Andrade FilhoRui Haddad
Feb 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Catherine E GarnerNorman M Ratcliffe
May 25, 2007·Cancer Biomarkers : Section a of Disease Markers·Michael PhillipsPeter Schmitt
Jan 22, 2008·Chemical Reviews·Frank RöckUdo Weimar
Feb 5, 2008·Applied and Environmental Microbiology·Michael BungeTilmann D Märk
Apr 19, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael PhillipsJames Wai
Apr 22, 2008·Molecular Diagnosis & Therapy·Akshay K GuptaD Kim Turgeon
May 29, 2008·Integrative Cancer Therapies·György HorvathIstván Horváth

❮ Previous
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Citations

Jan 19, 2016·Frontiers in Veterinary Science·T Craig AngleHerris S Maxwell
Jul 26, 2016·Frontiers in Veterinary Science·Craig AngleThomas Passler
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qin-Si Wan, Kun-He Zhang
Nov 14, 2017·Biomedical Chromatography : BMC·Simonetta CaponePietro Siciliano
Oct 25, 2017·Cancer Biomarkers : Section a of Disease Markers·Ingrid Oakley-Girvan, Sharon Watkins Davis
Nov 24, 2018·Biomedical Chromatography : BMC·Yi He, Marta Concheiro-Guisan
Dec 12, 2018·Journal of Breath Research·Ileana-Andreea RatiuBoguslaw Buszewski
Mar 1, 2019·Molecular Nutrition & Food Research·Carina I MackChiara Cordero
Apr 28, 2017·The European Respiratory Journal·Ildiko HorváthTeunis J Vink
Jun 28, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Reef Einoch AmorHossam Haick
Jul 10, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M McFarlaneC Nwokolo
Mar 5, 2020·Expert Review of Molecular Diagnostics·Subashini Chandrapalan, Ramesh P Arasaradnam
Oct 13, 2016·Journal of Breath Research·Sean W HarshmanClaude C Grigsby
Jul 19, 2017·Analytical and Bioanalytical Chemistry·Patricia Martín SantosBernardo Moreno Cordero
Jun 12, 2020·Journal of Biophotonics·Kiran Sankar MaitiAlexander Apolonski
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Daniela RodriguesMárcia Carvalho
Mar 7, 2020·Research : a Science Partner Journal·Huimin GongFei Wang
Feb 7, 2019·Frontiers in Veterinary Science·Astrid R ConchaDaniel S Mills
Apr 5, 2018·Scientific Reports·Ana Rita LimaPaula Guedes de Pinho
Dec 17, 2018·Journal of Cancer Research and Clinical Oncology·Sofie BoschNanne K de Boer
Nov 9, 2019·Scientific Reports·Kiran Sankar MaitiAlexander Apolonski
Nov 24, 2020·Journal of Breath Research·Rosa PeltriniSalman Siddiqui
Feb 13, 2021·Postgraduate Medical Journal·Rania SakrMarouan Zoghbi
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fernanda MonedeiroBogusław Buszewski
Dec 5, 2020·Medical Hypotheses·Ayman BannagaRamesh P Arasaradnam
Jun 16, 2021·Forensic Science International : Synergy·Julian MendelDeEtta Mills

❮ Previous
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