Current clinical practice and challenges in the management of secondary immunodeficiency in hematological malignancies

European Journal of Haematology
Il-Kang NaIsabella Quinti

Abstract

Despite long-standing safe and effective use of immunoglobulin replacement therapy (IgRT) in primary immunodeficiency, clinical data on IgRT in patients with secondary immunodeficiency (SID) due to B-cell lymphoproliferative diseases are limited. Here, we examine the correlation between approved IgRT indications, treatment recommendations, and clinical practice in SID. An international online survey of 230 physicians responsible for the diagnosis of SID and the prescription of IgRT in patients with hematological malignancies was conducted. Serum immunoglobulin was measured in 83% of patients with multiple myeloma, 76% with chronic lymphocytic leukemia, and 69% with non-Hodgkin lymphoma. Most physicians (85%) prescribed IgRT after ≥2 severe infections. In Italy, Germany, Spain, and the United States, immunoglobulin use was above average in patients with hypogammaglobulinemia, while in the UK considerably fewer patients received IgRT. The use of subcutaneous immunoglobulin was highest in France (34%) and lowest in Spain (19%). Immunologists measured specific antibody responses, performed test immunization, implemented IgRT, and used subcutaneous immunoglobulin more frequently than physicians overall. The management of SID in hema...Continue Reading

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Citations

Aug 20, 2020·American Journal of Clinical Dermatology·Roberto MaglieEmiliano Antiga
Jul 19, 2020·Journal of Medical Virology·Syed Ziauddin Ahmed ZaidiSyed Maaz Abdullah
Jan 19, 2021·Asia-Pacific Journal of Clinical Oncology·Tanja M WindeggerYoke-Lin Fung
Jan 17, 2021·European Journal of Haematology·Stephen JollesVincent Lévy
Feb 2, 2021·Cell Reports Medicine·Kazuhito HonjoRandall S Davis
Jun 27, 2020·Expert Review of Clinical Immunology·Vishesh Patel, Juthaporn Cowan
Mar 30, 2021·Frontiers in Medicine·Paraskevi PavlakouEvangelos Papachristou
Sep 6, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Karen S TuanoJavier Chinen

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