Abstract
Despite long-standing safe and effective use of immunoglobulin replacement therapy (IgRT) in primary immunodeficiency, clinical data on IgRT in patients with secondary immunodeficiency (SID) due to B-cell lymphoproliferative diseases are limited. Here, we examine the correlation between approved IgRT indications, treatment recommendations, and clinical practice in SID. An international online survey of 230 physicians responsible for the diagnosis of SID and the prescription of IgRT in patients with hematological malignancies was conducted. Serum immunoglobulin was measured in 83% of patients with multiple myeloma, 76% with chronic lymphocytic leukemia, and 69% with non-Hodgkin lymphoma. Most physicians (85%) prescribed IgRT after ≥2 severe infections. In Italy, Germany, Spain, and the United States, immunoglobulin use was above average in patients with hypogammaglobulinemia, while in the UK considerably fewer patients received IgRT. The use of subcutaneous immunoglobulin was highest in France (34%) and lowest in Spain (19%). Immunologists measured specific antibody responses, performed test immunization, implemented IgRT, and used subcutaneous immunoglobulin more frequently than physicians overall. The management of SID in hema...Continue Reading
References
Oct 6, 1988·The New England Journal of Medicine·UNKNOWN Cooperative Group for the Study of Immunoglobulin in Chronic Lymphocytic LeukemiaDierdre Tait
Sep 1, 1994·British Journal of Haematology·H ChapelM Lee
Apr 30, 1994·Lancet·H M ChapelA G Prentice
Nov 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley M AugustsonMark T Drayson
Apr 3, 2007·Transfusion Medicine Reviews·David AndersonGail Rock
Mar 18, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daihong LiuQian Jiang
Aug 30, 2008·British Medical Bulletin·A D Hamblin, T J Hamblin
Oct 23, 2008·Immunology and Allergy Clinics of North America·Melvin Berger
Mar 31, 2009·Leukemia & Lymphoma·Pia RaananiOfer Shpilberg
Aug 22, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·S AlmeidaS Frangou
Nov 26, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M S AaproUNKNOWN European Organisation for Research and Treatment of Cancer
Apr 27, 2011·British Journal of Haematology·John A SnowdenUNKNOWN Haemato-oncology Task Force of British Committee for Standards in Haematology and UK Myeloma Forum
Jun 26, 2012·Journal of Clinical Immunology·Hassan AbolhassaniNima Rezaei
Oct 13, 2012·British Journal of Haematology·David OscierUNKNOWN British Committee for Standards in Haematology
Jan 2, 2013·Clinical Lymphoma, Myeloma & Leukemia·Carla CasuloAndrew D Zelenetz
Feb 22, 2014·Journal of Clinical Immunology·Fatima DhallaHelen Chapel
Apr 1, 2014·Haematologica·Nicolò CompagnoCarlo Agostini
Jul 1, 2014·European Journal of Immunology·W A Carrock SewellHans-Hartmut Peter
Sep 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Blanka KaplanVincent Bonagura
Oct 26, 2014·Haematologica·Cecilie BlimarkSigurdur Y Kristinsson
Nov 12, 2014·Clinical and Experimental Immunology·S JollesM Berger
Dec 30, 2014·Frontiers in Immunology·Nicolò CompagnoCarlo Agostini
Dec 30, 2014·Clinical and Experimental Immunology·A ŠediváUNKNOWN European Immunoglobulin Map Group (35 European Countries) for European Society for Immunodeficiencies (ESID) Primary Immunod
Jul 15, 2016·Expert Review of Clinical Immunology·Carlo AgostiniTorben Plesner
Sep 7, 2016·Frontiers in Immunology·Silvia Sánchez-RamónHelen Chapel
Dec 22, 2016·Clinical and Experimental Immunology·S JollesJ Litzman
Jan 4, 2017·The Journal of Allergy and Clinical Immunology·Elena E PerezMark Ballow
May 4, 2017·European Journal of Haematology·Marcel ReiserManfred Hensel
Feb 10, 2018·Journal of Clinical Immunology·John David M EdgarUNKNOWN United Kingdom Primary Immunodeficiency Network (UKPIN) Immunoglobulin Decision to Treat Study Group
Citations
Aug 20, 2020·American Journal of Clinical Dermatology·Roberto MaglieEmiliano Antiga
Jul 19, 2020·Journal of Medical Virology·Syed Ziauddin Ahmed ZaidiSyed Maaz Abdullah
Jan 19, 2021·Asia-Pacific Journal of Clinical Oncology·Tanja M WindeggerYoke-Lin Fung
Jan 17, 2021·European Journal of Haematology·Stephen JollesVincent Lévy
Feb 7, 2021·Medicine·Chunmei YeJinlin Liu
Feb 2, 2021·Cell Reports Medicine·Kazuhito HonjoRandall S Davis
Feb 19, 2021·Leukemia & Lymphoma·Sujoy KhanDavid Allsup
Jun 27, 2020·Expert Review of Clinical Immunology·Vishesh Patel, Juthaporn Cowan
Mar 30, 2021·Frontiers in Medicine·Paraskevi PavlakouEvangelos Papachristou
Mar 14, 2021·British Journal of Haematology·Sarah GoddardJane Graham
Apr 29, 2021·Expert Review of Clinical Immunology·Michael BorteCorinna Hermann
May 17, 2021·Voprosy virusologii·T V SolomayE B Faizuloev
Jul 22, 2021·Hematological Oncology·Vishesh PatelJuthaporn Cowan
Jul 11, 2021·European Journal of Haematology·Valentin LacombeAline Schmidt
Aug 14, 2021·Hematology·Weiwei ChenJinlin Liu
Sep 6, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Karen S TuanoJavier Chinen
Sep 28, 2021·Leukemia & Lymphoma·Rajiv MallickDonald C Vinh
Oct 16, 2021·PloS One·S Shahzad MustafaAllison Ramsey
Oct 28, 2021·Leukemia & Lymphoma·Stephen JollesVictoria Divino
Jan 26, 2022·Hematological Oncology·Idanna InnocentiLuca Laurenti
Jan 26, 2022·Med·Katie HealyMargaret Sällberg Chen