Current CML therapy: progress and dilemma

Leukemia
R Hehlmann

Abstract

Rarely has progress in treatment of leukemia been as dramatic and convincing as with the BCR-ABL tyrosine kinase inhibitor imatinib.(1) Imatinib induces remissions of CML as fast as hydroxyurea, achieves rates of cytogenetic remissions that by far exceed those induced by interferon alpha and has a toxicity profile as favourable as that of hydroxyurea and much superior to that of interferon alpha.(2) In addition, the causal approach of this new drug, which may well serve as a model for new treatment modalities in other neoplasias is reassuring.

References

Apr 2, 1998·The New England Journal of Medicine·J A HansenC Anasetti
Apr 5, 2001·The New England Journal of Medicine·B J DrukerC L Sawyers
Nov 8, 2001·Blood·F BonifaziUNKNOWN Swedish CML Study Group
Mar 1, 2002·The New England Journal of Medicine·Hagop KantarjianUNKNOWN International STI571 CML Study Group
Mar 15, 2003·The New England Journal of Medicine·Stephen G O'BrienUNKNOWN IRIS Investigators

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Citations

Jul 31, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ingo Roeder, Ingmar Glauche
Jan 27, 2007·Journal of Translational Medicine·Annette M MarleauThomas E Ichim
Apr 15, 2005·Leukemia·U BergerUNKNOWN German CML-Study Group
Jul 20, 2006·International Journal of Clinical Oncology·Ryuzo Ohno
Mar 23, 2011·Expert Review of Anticancer Therapy·Jerry L Spivak, Hans Hasselbalch
May 6, 2008·Biochemical Pharmacology·Yun-Bin YeMichel Vidal
Feb 6, 2004·Hematological Oncology
Nov 26, 2010·The Mount Sinai Journal of Medicine, New York·Stacey J Baker, E Premkumar Reddy
Mar 31, 2015·Molecular Pharmacology·Mei-Chuan ChenYun Yen

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