This article discusses the unique properties of the fetal cardiovascular system and patterns of blood flow in congenital heart disease. It also explores the complex interactive dependency between the developing heart and pulmonary vasculature, with particular attention to hypoplastic left heart syndrome. The article goes on to highlight some recent advances in the understanding of fetal cardiovascular medicine, specifically the possibilities and prognosis for fetal cardiac interventions. An understanding of the enigmatic process of twin-twin transfusion syndrome may help in elucidating one of the mechanisms for development of cardiac structural abnormalities in the fetus.
Quantitative structural study of pulmonary circulation in the newborn with aortic atresia, stenosis, or coarctation
Indomethacin does not diminish the pulmonary vascular response of the fetus to increased oxygen tension
Role of angiotensin II on the adrenal and vascular responses to hemorrhage during development in fetal lambs
Ten-year institutional experience with palliative surgery for hypoplastic left heart syndrome. Risk factors related to stage I mortality
Clinical and echographic features of in utero cardiac dysfunction in the recipient twin in twin-twin transfusion syndrome
Assessment of changes in blood flow through the lungs and foramen ovale in the normal human fetus with gestational age: a prospective Doppler echocardiographic study
Correlations of placental vascular anatomy and clinical outcomes in 69 monochorionic twin pregnancies
Role of the pulmonary circulation in the distribution of human fetal cardiac output during the second half of pregnancy
Reactivity of the human fetal pulmonary circulation to maternal hyperoxygenation increases during the second half of pregnancy: a randomized study
X-chromosome inactivation patterns do not implicate asymmetric splitting of the inner cell mass in the aetiology of twin-twin transfusion syndrome
Prenatal features of ductus arteriosus constriction and restrictive foramen ovale in d-transposition of the great arteries
Endoscopic laser surgery versus serial amniocenteses in the treatment of severe twin-twin transfusion syndrome
Prenatal diagnosis of right ventricular outflow tract obstruction with intact ventricular septum, and detection of ventriculocoronary connections
The hypoplastic left heart syndrome with intact atrial septum: atrial morphology, pulmonary vascular histopathology and outcome
Obstetric and perinatal outcomes from the australian and new zealand twin-twin transfusion syndrome registry
Fetal origins of reduced arterial distensibility in the donor twin in twin-twin transfusion syndrome
Endoscopic laser coagulation of placental anastomoses in 200 pregnancies with severe mid-trimester twin-to-twin transfusion syndrome
Perinatal morbidity and mortality rates in severe twin-twin transfusion syndrome: results of the International Amnioreduction Registry
Acquired right ventricular outflow tract obstruction in the recipient twin in twin-twin transfusion syndrome
Outcome for children born after in utero laser ablation therapy for severe twin-to-twin transfusion syndrome
The influence of a restrictive atrial septal defect on pulmonary vascular morphology in patients with hypoplastic left heart syndrome
Influence of twin-twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnancies
Prenatal prediction of lethal pulmonary hypoplasia: the hyperoxygenation test for pulmonary artery reactivity
Video-assisted thoracoscopic ligation of a patent ductus arteriosus in a very low-birth-weight infant using a novel retractor
Is aerobic workload positively related to ambulatory blood pressure? A cross-sectional field study among cleaners
Non-invasive in vivo measurement of cardiac output in C57BL/6 mice using high frequency transthoracic ultrasound: evaluation of gender and body weight effects
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