Current Concepts in Pediatric Nonalcoholic Fatty Liver Disease

Gastroenterology Clinics of North America
Sarah E FleetJoel E Lavine

Abstract

Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of disease. Its increasing prevalence is a direct result of historically high rates of obesity. Hepatocyte lipid accumulation is the first step in a cascade of metabolic and inflammatory events thought to precipitate NAFLD. Histologic findings provide insight into these events. Lifestyle modification remains the primary therapy in children. Current recommendations include vitamin E treatment in those with biopsy-proven NASH. Trials of novel drugs are ongoing in adults. As efficacy/safety are established, these therapies may be tenable for use in children. At the current time, biopsy-driven histology endpoints are necessary to establish whether future therapies can improve pediatric or adult-type NASH in children.

Citations

Dec 19, 2017·Frontiers in Pharmacology·Lishan ZhouSuqi Yan
Dec 10, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Valerio NobiliChristopher D Byrne
Jan 8, 2019·Metabolic Syndrome and Related Disorders·Hüseyin KurkuYavuz Turgut Gederet
Feb 2, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alessandro MantovaniGiovanni Targher
Aug 24, 2018·Pediatric Research·Vandana JainAnil Dhawan
Mar 27, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni TargherValerio Nobili
Oct 24, 2020·Nature Reviews. Gastroenterology & Hepatology·Sven FrancqueFrank Tacke

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