PMID: 6988473Apr 1, 1980Paper

Current concepts in the classification of connective tissue diseases. Overlap syndromes and mixed connective tissue disease (MCTD)

Journal of the American Academy of Dermatology
G C Sharp, P C Anderson

Abstract

New principles are discussed for the classification of the diffuse collagen diseases, particularly the mixed connective tissue disease (MCTD), with clinical and historical explanation. Emphasis in classification has shifted from a concern with tissue pathology to serologic anomalies, which may involve eleven different antigens, many from human cell nuclei. New serologic tests, such as the ribonucleoprotein (RNP) antibody test, may be superior to the well-known fluorescent antinuclear antibody (ANA) studies for diagnosis and follow-up of diffuse collagen diseases. Functional clinical studies, such as esophageal motility, gas exchange in the lung, and major joint mobility, which may appear early in MCTD, are more important to diagnosis than anatomic studies of late-developing lesions.

References

Jun 1, 1977·The Journal of Pediatrics·B H SingsenE M Tan
Sep 1, 1978·Arthritis and Rheumatism·D A Norman, R M Fleischmann
Jan 1, 1977·The Journal of Clinical Investigation·J F WolfeG C Sharp
May 1, 1977·Arthritis and Rheumatism·R OxenhandlerE Adelstein
Jun 1, 1978·Arthritis and Rheumatism·J T Halla, J G Hardin
Feb 1, 1975·British Medical Journal·D KitchinerG R Hughes
Oct 1, 1975·Annals of Internal Medicine·D D NotmanE M Tan
Jul 1, 1975·Annals of Internal Medicine·P M LevitinV J Giuliano
Jan 1, 1967·Acta Rheumatologica Scandinavica·F Lenoch, O Vojtísek
Mar 1, 1955·Journal of Chronic Diseases·J R HASERICK

Citations

Oct 19, 2000·Arthritis and Rheumatism·A BrunsF Hiepe
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·N UedaH Fukuzaki
Dec 1, 1984·Clinical Rheumatology·J CalderonJ Gomez-Reyno
Jan 26, 1999·Clinics in Chest Medicine·U B Prakash
Oct 30, 2013·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·D C FerreiraM A B Cavalcante
Apr 1, 1984·The Journal of Dermatology·T ShishibaS Hasegawa
Jul 6, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·P J Maddison
Oct 1, 2011·Seminars in Arthritis and Rheumatism·Susanna CappelliMarco Matucci Cerinic
Oct 1, 1992·Clinics in Dermatology·S JablonskaE H Beutner
Sep 1, 1982·Clinical and Experimental Dermatology·E NunziA Rebora
Jan 1, 1981·Journal of the American Academy of Dermatology·T K Burnham
Oct 1, 1984·Oral Surgery, Oral Medicine, and Oral Pathology·A M Rich, P C Reade
Aug 1, 1982·The Australasian Journal of Dermatology·H O Perry
Apr 1, 1997·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·H B WeissJ H Coben
Feb 1, 1984·American Journal of Medical Genetics·D O SillenceD L Rimoin
Sep 1, 1989·British Journal for the History of Science·N Roll-Hansen
Jun 1, 1981·The British Journal of Dermatology·C M Black
Oct 1, 1990·The British Journal of Dermatology·M BłaszczykV Kumar
Dec 1, 1983·The Journal of Dermatology·Y KobayashiS Sano
Jun 1, 1985·Journal of Cutaneous Pathology·L E Golitz

Related Concepts

Connective Tissue Diseases
Differential Diagnosis
Immunofluorescence Assay
Antibody Dissociation
Lupus Erythematosus, Systemic
Mixed Connective Tissue Disease

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