Current Concepts of Anatomy, Electrophysiology, and Therapeutic Implications of the Interatrial Septum

JACC. Clinical Electrophysiology
Rohit K KharbandaNatasja M S de Groot

Abstract

The interatrial septum (IAS), a fibromuscular structure separating the right (RA) and left (LA) atrium, plays an important role in both intra- and interatrial conduction. Electropathological changes in the IAS such as discordant activation of the right and left septal layer and conduction disorders may facilitate intraseptal re-entry and promote development of atrial tachyarrhythmias such as atrial fibrillation (AF). Various experimental studies have emphasized the importance of the IAS in AF initiation and perpetuation. Moreover, a thicker IAS has been associated with atrial tachyarrhythmias and a lower success rate of catheter ablation. Therefore, it is assumed that the septal interatrial connections, which may be more pronounced in patients with a thicker IAS, may furnish an anatomic pathway for re-entry and may explain failure of catheter ablation therapy. However, the exact role of the IAS in the treatment of AF still remains an enigma. More profound understanding of the role of the IAS in the pathophysiology of AF and other atrial tachyarrhythmias is necessary to improve success of current therapeutic options and develop new treatment modalities. This review outlines the current knowledge on the relationship between anato...Continue Reading

References

Aug 1, 1979·American Heart Journal·L J Sweeney, G C Rosenquist
Feb 1, 1990·The Annals of Thoracic Surgery·B C ChangJ L Cox
Jul 1, 1971·American Heart Journal·A M Hutter, D L Page
Nov 1, 1971·Circulation Research·A L WaldoB F Hoffman
Jan 1, 1971·The American Journal of Physiology·D GoodmanR T van Dam
Oct 1, 1965·Circulation Research·M Vassalle, B F Hoffman
May 1, 1966·Circulation Research·M L WagnerB F Hoffman
Dec 12, 1997·Journal of Cardiovascular Electrophysiology·C TondoR Lazzara
Nov 24, 1998·Pacing and Clinical Electrophysiology : PACE·A KatsivasN Louvros
Dec 3, 1998·Journal of Cardiovascular Electrophysiology·R H Anderson, S Y Ho
Jun 4, 1999·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·L PadelettiG F Gensini
Aug 27, 1999·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·R H AndersonN A Brown
Apr 20, 2001·Pacing and Clinical Electrophysiology : PACE·F X RoithingerF Hintringer
Jun 18, 2002·Heart·Robert H AndersonSandra Webb
Nov 6, 2002·The American Journal of Geriatric Cardiology·Angel López-Candales
Apr 2, 2003·The American Journal of Cardiology·Yogesh K AgarwalDavid H Spodick
Jun 14, 2003·The American Journal of Cardiology·Robert LemeryJohn P Veinot
Jan 1, 1958·Circulation·T N JAMES, G E BURCH
Dec 18, 2003·Journal of Cardiovascular Electrophysiology·Luigi PadelettiUNKNOWN Worldwide ASPECT Investigators
May 12, 2004·Circulation·Nassir F MarroucheMelvin M Scheinman
Jun 3, 2004·Journal of the American College of Cardiology·Koonlawee NademaneeTachapong Ngarmukos
Nov 1, 2005·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Marco BudeusStefan Sack
Jan 31, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Sunny S PoWarren M Jackman
Aug 19, 2007·Journal of Cardiovascular Medicine·Roberto VerlatoGiorgio Corbucci

❮ Previous
Next ❯

Citations

Jun 26, 2020·Journal of Cardiovascular Electrophysiology·Domenico G Della RoccaAndrea Natale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Pyotr G PlatonovS B Olsson
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Nina HakacovaThomas A Buckingham
© 2021 Meta ULC. All rights reserved