Current Concepts of Metastasis Formation

Cancers
Jörg Haier, Peter Gassman

Abstract

The development of secondary distant organ and lymph node metastasis has an extraordinary impact on the prognosis of patients with solid cancer. In most cases the advent of metastatic growth represents the turning point from a local, potentially curable, disease to a systemic non-curable situation. As a highly regulated process, metastasis formation follows a distinct, non-random pattern characteristic for each tumor entity. Metastasis formation and strategies to prevent this lethal event in the progression of cancer is of fundamental interest for cancer science and patient care. In this special issue of Cancers, papers highlighting cellular mechanisms of metastasis formation, genetic and epigenetic aspects associated with organ and tumor specific metastasis formation, as well as papers outlining experimental and clinical therapeutic concepts for anti-metastatic treatment are included. [...].

References

May 24, 2011·Cancers·Megan N ThobeCarrie W Rinker-Schaeffer
Jan 1, 2010·Cancers·William E DamskyMarcus Bosenberg
Jan 1, 2011·Cancers·Alexey Navdaev, Johannes A Eble
Jan 1, 2011·Cancers·Xuesong WuSam T Hwang
Jan 1, 2010·Cancers·Alexander Chi, Ritsuko Komaki

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