Current concepts of the podocyte in nephrotic syndrome

Kidney Research and Clinical Practice
Wen Y Ding, Moin A Saleem

Abstract

Nephrotic syndrome is a disorder of the glomerular filtration barrier, and central to the filtration mechanism of the glomerular filtration barrier is the podocyte. We are starting to better understand how this cell, with its unique architectural features, fulfils its exact filtration properties. The multiprotein complex between adjacent podocyte foot processes, the slit diaphragm, is essential to the control of the actin cytoskeleton and cell morphology. Many of the proteins within the slit diaphragm, including nephrin, podocin, transient receptor potential-6 channel, and α-actinin-4, have been identified via genetic studies of inherited nephrotic syndromes. Signaling from slit diaphragm proteins to the actin cytoskeleton is mediated via the Rho GTPases. These are thought to be involved in the control of podocyte motility, which has been postulated as a focus of proteinuric pathways. Nephrotic syndrome is currently treated with immunosuppressive therapy, with significant adverse effects. These therapies may work in nephrotic syndrome due to specific effects on the podocytes. This review aims to describe our current understanding of the cellular pathways and molecules within the podocyte relevant to nephrotic syndrome and its t...Continue Reading

References

Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·V RuotsalainenK Tryggvason
Sep 20, 2001·The Journal of Biological Chemistry·T B HuberT Benzing
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Moin A SaleemPeter Mundel
Jul 2, 2003·Molecular and Cellular Biology·Tobias B HuberThomas Benzing
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Matthias KrauseFrank B Gertler
Jan 22, 2005·Journal of the American Society of Nephrology : JASN·Richard J M CowardMoin A Saleem
Jul 1, 2005·Journal of the American Society of Nephrology : JASN·Takehiko WadaStuart J Shankland
Mar 21, 2006·European Journal of Cell Biology·Nicole Endlich, Karlhans Endlich
Apr 20, 2006·Nature Cell Biology·Katsuhiko AsanumaPeter Mundel
May 19, 2006·Nephron. Experimental Nephrology·Joanna Marszal, Moin A Saleem
Jul 14, 2006·Kidney International·C-Y XingP W Mathieson
Mar 21, 2007·Pediatrics·Bernward G HinkesUNKNOWN Arbeitsgemeinschaft für Paediatrische Nephrologie Study Group
Aug 24, 2007·American Journal of Physiology. Renal Physiology·Christopher R NealDavid O Bates
Sep 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Astrid WeinsMartin R Pollak
Nov 2, 2007·EMBO Reports·Dominique T Brandt, Robert Grosse
Dec 18, 2007·Nature Medicine·Changli WeiJochen Reiser
Aug 8, 2008·American Journal of Physiology. Renal Physiology·Moin A SaleemPeter W Mathieson
Aug 30, 2008·Journal of the American Society of Nephrology : JASN·Rachel LennonMoin A Saleem
Feb 28, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pierre CochatLothar Bernd Zimmerhackl
Mar 7, 2009·Molecular Endocrinology·Siwei LiZhixiang Wang
Apr 16, 2009·Biochimica Et Biophysica Acta·Michel R Popoff, Blandine Geny
May 22, 2009·Cell Motility and the Cytoskeleton·Aditya S Paul, Thomas D Pollard
Aug 21, 2009·Nature·Matthias MachacekGaudenz Danuser
Sep 18, 2009·Developmental Cell·Robert H Insall, Laura M Machesky
Nov 13, 2009·Current Biology : CB·Alex Mogilner, Kinneret Keren
Dec 10, 2009·Nature Reviews. Molecular Cell Biology·Melissa A ChesaroneBruce L Goode
Jan 15, 2010·American Journal of Physiology. Renal Physiology·Jianxin ZhuTomoko Takano
Jan 21, 2010·The Journal of Biological Chemistry·Jane H KimJohn R Sedor
Apr 21, 2010·The Journal of Biological Chemistry·Trynette J van DuijnPeter L Hordijk
Jun 26, 2010·Journal of the American Society of Nephrology : JASN·János Peti-Peterdi, Arnold Sipos
Aug 6, 2010·American Journal of Physiology. Renal Physiology·Stuart E Dryer, Jochen Reiser
Jan 25, 2011·Journal of the American Society of Nephrology : JASN·Olivia BoyerCorinne Antignac
May 26, 2011·Current Opinion in Nephrology and Hypertension·Joseph P LySusan E Quaggin
Jun 3, 2011·Science Translational Medicine·Alessia FornoniGeorge W Burke
Jun 23, 2011·Clinical and Experimental Nephrology·Teiko OhashiKosaku Nitta

❮ Previous
Next ❯

Citations

Apr 21, 2017·Journal of the American Society of Nephrology : JASN·Ruchika SharmaBryce A Kerlin
Apr 1, 2018·Journal of the American Society of Nephrology : JASN·Yoshiyasu FukusumiHiroshi Kawachi
Oct 4, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Adam R BensimhonRasheed A Gbadegesin
Jun 14, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tae-Sun HaJae Il Shin
Nov 28, 2017·Nature Reviews. Nephrology·Shipra AgrawalWilliam E Smoyer
Sep 29, 2018·Lab on a Chip·Anastasia KoroljBoyang Zhang
Mar 2, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Susan VeissiJitske Jansen
Nov 28, 2019·International Journal of Endocrinology·Yohei AsadaAtsushi Suzuki
Aug 15, 2015·Molecular and Cellular Biochemistry·Barbara LewkoJan Stępiński
Jan 21, 2021·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kyle J HampsonMolly E Band

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
electron microscopy
GTPases
GTPase

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephron. Experimental Nephrology
Hugh J McCarthy, Moin A Saleem
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Moin A Saleem
Nature Clinical Practice. Nephrology
Duncan B Johnstone, Lawrence B Holzman
International Journal of Nephrology
Maddalena GiganteFilippo Aucella
© 2022 Meta ULC. All rights reserved