PMID: 8601570Jan 1, 1996Paper

Current concepts of treatment in medical oncology: new anticancer drugs

Journal of Cancer Research and Clinical Oncology
C Unger

Abstract

General principles for anticancer drug development include traditional drug-screening methods in biological test systems. Today, testing of a drug in a panel of selected human tumor xenografts in mice is assumed to have the best predictive value for clinical efficacy. Chemical modification of well-known antitumor drugs from compound groups such as purine analogs, vinca alkaloids, antifolates and platinum analogs are carried out to increase anticancer activity, to reduce toxic side-effects and to improve pharmacokinetic properties of the drugs. In the last decade the enormous development in molecular techniques has led to the discovery of key proteins that are intimately involved in the regulation of cancer growth control. Cell growth inhibitors could be developed by structure-based design, creating small organic molecules ("peptide mimetics") to target crucial enzymes, oncogenes or oncogene products, tumor-suppressor genes and their products as well as growth factors and their corresponding receptors. Drugs representing new leading structures, like alkylphosphocholines, topoisomerase I inhibitors, taxoids and suramin, have already entered the clinic. Novel therapeutic approaches may provide substantial progress in cancer treatm...Continue Reading

References

Oct 17, 1992·Lancet·E Beutler
Jul 2, 1992·Nature·D P Lane
Jan 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T P MillerS E Salmon
Sep 1, 1990·Cancer Treatment Reviews·H Eibl, C Unger
Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D AbigergesD Gandia
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·A L KranichG A Nagel
Jan 1, 1994·Cancer Treatment Reviews·G J CreemersJ Verweij
Jan 1, 1993·Cancer Chemotherapy and Pharmacology·P HilgardC Unger

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Citations

Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·P HilgardJ Engel
Jul 5, 2005·Expert Opinion on Investigational Drugs·M S Sachdeva
Aug 6, 1999·Cancer Investigation·A Lupulescu
Sep 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaoyang QiTimothy P Cripe

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