PMID: 8966395Jul 1, 1996Paper

Current concepts on cartilage collagens and their association with disease

Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
A L Weckmann, A R Cabral

Abstract

The main functional role of the collagenous cartilage fibers is to form a stable network to counteract the hydrodynamic pressure generated by the highly hydrodynamic proteoglycan aggregates. The main collagen present in human cartilage is type II, but other proteins such as type IV, VI, IX, X, XI and XIV are also found albeit in small quantities. Several transgenic mice have been developed to study the structural abnormalities as they relate to human disease. Similarly, the study of these structural abnormalities has renewed the interest regarding their pathogenetic role in some hereditary and acquired diseases of cartilage in humans. It is hoped that gene therapy will help correct these abnormalities. We review here these topics.

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
M van der Rest, R Garrone
Biochimica Et Biophysica Acta
J R Sellers
© 2021 Meta ULC. All rights reserved