Current data on the background burden to the persistent organochlorine pollutants HCB, p,p'-DDE as well as PCB 138, PCB 153 and PCB 180 in plasma of the general population in Germany

International Journal of Hygiene and Environmental Health
Thomas SchettgenThomas Kraus

Abstract

Despite their long-term ban, persistent organochlorine compounds like hexachlorobenzene (HCB), p,p'-dichlorodiphenylethylene (DDE) as well as polychlorinated biphenyls (PCBs) are still of environmental concern. For the evaluation of potential occupational or environmental exposures to these substances, it is essential to know the current background burden of the general population. As representative and up-to-date information is missing for Germany, we have analysed a large dataset generated in studies on potential exposure to lower chlorinated PCBs to fill this gap for the levels of HCB, DDE as well as PCB 138, PCB 153 and PCB 180. We have investigated n=2750 plasma samples of persons of the general population living in North Rhine-Westfalia and Hesse aged 6-65 years and sampled between September 2010 and March 2014. For evaluation of the age-dependent accumulation in the general population we have generated seven age groups in the collective. Our laboratory used a validated and quality controlled procedure using GC/MS for quantification of the organochlorine compounds in plasma (LOQ: 0.01μg/L). The median (95th percentile) levels for ∑ PCB 138+PCB 153+PCB 180 were 0.14 (0.73); 0.30 (0.82); 0.38 (0.88); 0.50 (1.14); 0.92; 1.58...Continue Reading

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Citations

Mar 24, 2016·International Journal of Environmental Research and Public Health·Hajo HaaseLothar Rink
Apr 14, 2016·International Journal of Hygiene and Environmental Health·Hermann FrommeWolfgang Völkel
Jul 12, 2016·International Journal of Hygiene and Environmental Health·André EsserThomas Kraus
Mar 10, 2017·International Journal of Hygiene and Environmental Health·Juan José RamosUNKNOWN Bioambient.es
Nov 15, 2017·International Journal of Environmental Research and Public Health·Pallavi P BalteWilfried J J Karmaus
Jan 27, 2018·Biomédica : revista del Instituto Nacional de Salud·Boris Santiago Ávila, Carolina Ramírez
Apr 8, 2020·Journal of Toxicology and Environmental Health. Part a·André EsserThomas Kraus
Jun 9, 2018·Journal of Occupational Medicine and Toxicology·Sahar EftekhariAndré Esser
Jul 6, 2018·Journal of Immunotoxicology·Lucie Leung-GurungChristine Broussard
Mar 20, 2019·International Journal of Environmental Research and Public Health·Petra Maria GaumJessica Lang
Jul 8, 2020·International Journal of Environmental Research and Public Health·Petra Maria GaumJessica Lang
Dec 12, 2020·International Journal of Hygiene and Environmental Health·André EsserThomas Schettgen
Jul 27, 2018·The Science of the Total Environment·Marike M LeijsJens M Baron

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