Current developments in opioid therapy for management of cancer pain

The Clinical Journal of Pain
Oscar A de Leon-Casasola

Abstract

Pain remains a highly prevalent problem for patients with cancer and typically falls into one of 3 types: visceral, somatic, and neuropathic. A mechanistic, pathophysiologic approach to pain management involves a good assessment of the type of pain, followed by tailoring of the treatment based on the diagnosis. This pain management strategy can provide rapid pain control with a lower incidence of complications and side effects than other methods. Furthermore, pharmacogenetics may play an important role in individualizing therapies in the future, but for now this type of data offers explanations for phenomena commonly observed in clinical practice, such as (1) differences in individual analgesic and side-effect responses to various opioid agents, (2) incomplete cross-tolerance seen when switching between mu opioid analgesics, and (3) why opioid rotation can be beneficial for patients after an opioid therapy loses efficacy or becomes associated with intolerable side effects. Especially for difficult-to-manage pain patients, additions to the opioid analgesic armamentarium can potentially better individualize pain management, and provide another option to be used for opioid rotation. Among the most recent Food and Drug Administrati...Continue Reading

References

Sep 1, 1990·Bio/technology·D McCormick, L Miller
Sep 1, 1988·Clinical Pharmacology and Therapeutics·D S WeinbergK M Foley
Mar 1, 1987·The Medical Clinics of North America·R Payne
Mar 22, 1996·Annals of the New York Academy of Sciences·T ReisineM Tallent
Jul 1, 1995·Reviews in the Neurosciences·T J Grudt, J T Williams
Sep 20, 1996·Neuroscience Letters·G C RossiG W Pasternak
Dec 22, 1999·Nature Neuroscience·J M MitchellH L Fields
Jun 10, 2000·Science·C J Woolf, M W Salter
Apr 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J W OliverF J Meyers
Aug 14, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·G W Pasternak
Jan 9, 2003·The American Journal of Medicine·Janyce F RogersJoseph S Bertino
Aug 9, 2003·Journal of Pain and Symptom Management·Sebastiano MercadanteEdoardo Arcuri
Nov 19, 2003·Archives of Neurology·Robert H DworkinSharon M Weinstein
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin StocklerDavid Warr
Feb 11, 2005·Journal of Clinical Pharmacology·Michael AdamsHarry Ahdieh
Apr 12, 2005·Drugs·Andrew I R ScottSusan Stewart
Nov 22, 2005·Expert Opinion on Drug Delivery·John N Staniforth, Anand R Baichwal
Dec 24, 2005·Clinical Pharmacokinetics·Mona DarwishJeffrey Thompson
Apr 21, 2006·Expert Review of Neurotherapeutics·Gabriela Rocha Lauretti
Oct 17, 2006·Expert Opinion on Investigational Drugs·Lynn R Webster
Dec 29, 2006·Annals of the New York Academy of Sciences·Athina VadaloucaEleni Moka
Mar 14, 2007·Journal of Pain and Symptom Management·Oscar A de Leon-Casasola

❮ Previous
Next ❯

Citations

Nov 9, 2010·European Journal of Clinical Pharmacology·Alexander M PonizovskyNathan I Cherny
Jul 28, 2011·European Journal of Clinical Pharmacology·Alexander M PonizovskyEdwin E Zvartau
Jul 9, 2013·Molecular Neurobiology·Damien P Kuffler
Jan 20, 2010·The Clinical Journal of Pain·Charles E Argoff
Jul 21, 2011·Journal of Anaesthesiology, Clinical Pharmacology·Deepak ThapaVanita Ahuja
Oct 7, 2011·Indian Journal of Palliative Care·Balaji P DuraisamyMaryann A Muckaden
Apr 22, 2010·Current Opinion in Supportive and Palliative Care·Robert Horton, Graeme Rocker
Aug 15, 2012·Journal of Pain and Symptom Management·Hsueh-Hsing PanKwua-Yun Wang
Feb 18, 2010·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Chris Pasero
Nov 17, 2009·Primary Care·Barbara RevilleRebecca Maury
May 19, 2009·Seminars in Oncology Nursing·Judith A Paice
Jul 1, 2014·Journal of Pain and Symptom Management·Julia RileyJoy Ross
Aug 16, 2016·Current Problems in Cancer·Alessandro Villa, Stephen Sonis
Sep 27, 2014·International Journal of Dentistry·Scilla SparabombeAngelo Putignano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.