PMID: 11332930May 3, 2001Paper

Current diagnosis, management and morbidity in paediatric inflammatory bowel disease

Acta Paediatrica
C SprayM S Murphy

Abstract

In the 1970s several reports highlighted the long delay in diagnosis often experienced by children with Crohn's disease. In recent years this disorder has attracted much publicity, and many believe that the incidence has increased substantially. The aim of this investigation was to determine whether heightened awareness had shortened the interval to diagnosis, improved clinical management and reduced morbidity. A retrospective study was therefore carried out on 112 children with inflammatory bowel disease (64 Crohn's disease, 41 ulcerative colitis, 7 indeterminate colitis) referred to a paediatric gastroenterology department in the UK between 1994 and 1998. In Crohn's disease the median interval to diagnosis was 47 wk (maximum 7 y). In those without diarrhoea this was longer (66 vs 28 wk; p = 0.005). In ulcerative colitis the median interval was 20 wk (maximum 3 y). Even in severe colitis the median interval was 5.5 wk (range 3-9 wk) and 4 required urgent colectomy soon after referral. Many with unrecognized Crohn's disease had undergone inappropriate treatments, such as growth hormone or psychiatric therapy. Nineteen (17%) had undergone endoscopic investigations in adult units prior to referral. Malnutrition was equally common...Continue Reading

Citations

Jun 1, 2007·Inflammatory Bowel Diseases·M Stephen Murphy
Feb 13, 2008·Inflammatory Bowel Diseases·Robert HeuschkelAnne Griffiths
Jun 6, 2013·BioMed Research International·Annalisa MarcuzziSergio Crovella
Dec 22, 2010·Journal of Crohn's & Colitis·Freerk Prenzel, Holm H Uhlig
Nov 13, 2003·Archives of Disease in Childhood·R J M CowardW G van't Hoff
Nov 13, 2003·Archives of Disease in Childhood·A Sawczenko, B K Sandhu
May 4, 2007·Archives of Disease in Childhood·A F RodriguesM S Murphy
May 6, 2008·BMJ : British Medical Journal·M Stephen Murphy
Jun 27, 2002·Expert Opinion on Pharmacotherapy·A Ronald F Bremner, R Mark Beattie
Dec 19, 2003·Expert Opinion on Pharmacotherapy·Alan Ronald BremnerRobert Mark Beattie
Oct 1, 2003·Journal of Chiropractic Medicine·Jonathan Williams, Thomas Bergmann
Oct 18, 2003·Gastroenterology Clinics of North America·Petar MamulaRobert N Baldassano
Mar 11, 2009·Journal of Medical Microbiology·Kevin G J PollockJohn M Cowden
Sep 27, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J V Arcos-MachancosesA Pereda-Pérez

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