PMID: 16507393Mar 2, 2006Paper

Current directions for COX-2 inhibition in breast cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Louis W C ChowMasakazu Toi

Abstract

Chemotherapy is effective against breast cancer. COX-2 has been implicated in the progression and angiogenesis of cancers. Celecoxib, a cyclooxygenase type 2 (COX-2) inhibitor, has both apoptotic and antiangiogenic activities, and may be of use in treatment of breast tumors which overexpress the COX-2 enzyme. Preliminary clinical trials have shown that the combination of chemotherapy with celecoxib has minimal additional toxicity and it may enhance the effects of the chemotherapy. Beside chemotherapy, celecoxib may promulgate the effect of aromatase inhibitor in breast cancer cells. Animal studies have shown that there are fewer and smaller tumors treated by combining exemestane and celecoxib. Larger clinical trials should be initiated to study the potential anti-cancer effects of celecoxib in breast cancer.

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Citations

Feb 8, 2013·Cell & Bioscience·Viola AllajDaotai Nie
Nov 10, 2015·European Journal of Pharmacology·Rui LiuGui-Shan Tan
May 9, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Seong Min KimSeok Joo Han
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Jan 23, 2016·Chemistry : a European Journal·Michael BrownThomas Wirth
Jun 14, 2019·Biotechnology and Applied Biochemistry·Marzieh MarzbanyMahsa Rasekhian
Sep 15, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Xiaoyang SunXiaohui Chen
Dec 3, 2020·International Journal of Molecular Sciences·Erika Aparecida SilveiraCesar de Oliveira
Dec 28, 2019·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Manikandan AlagumuthuNapoleon Ayyakannu Arumugam

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