PMID: 20105132Jan 29, 2010Paper

Current drug targets for antihyperlipidemic therapy

Mini Reviews in Medicinal Chemistry
Kishor S JainDilpesh P Jain

Abstract

Elevated lipid level is supposed to be one of the main risk factors of atherosclerosis and related cardiovascular diseases and stroke (and is connected to mortality and morbidity). Therefore, lipid lowering is one of the major approaches in prevention of coronary heart diseases and stroke. Though drugs of various categories acting through different mechanisms are available in the antihyperlipidemic therapy, there are still a few problems associated with the currently available lipid lowering drugs. Therefore, medicinal chemists worldwide are designing, synthesizing and evaluating a variety of new molecules for antihyperlipidemic activity to address these problems. One of the important approaches to this is identifying new drug targets for antihyperlipidemic activity. This review summarizes nineteen recently identified and currently being exploited targets for the ongoing research by researchers world over to discover novel leads as potential drugs for antihyperlipidemic therapy.

Citations

Jul 6, 2011·Journal of Medicinal Chemistry·Hanley N Abramson
Aug 16, 2014·European Journal of Medicinal Chemistry·Nikhilesh AryaKishor S Jain
Aug 20, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Panneerselvam VijayarajVasanthi Nachiappan
Feb 18, 2014·European Journal of Medicinal Chemistry·Nikhilesh AryaKishor S Jain
Nov 8, 2016·Cholesterol·Naveen Yelaware Puttaswamy, Asna Urooj
Aug 15, 2019·Protein Science : a Publication of the Protein Society·Vinh H NguyenMarie E Fraser
Aug 17, 2021·Oxidative Medicine and Cellular Longevity·Muhammad Farrukh NisarChunpeng Craig Wan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.