Abstract
In the last decade, cumulative epidemiological evidence suggested that vascular- and metabolic-based risk factors may be important in the development of mild cognitive impairment and dementia. Epidemiological and basic research have also proposed a model of cognitive impairment linked to metabolic syndrome (MetS) and metabolic disorders, suggesting for research purposes a "metabolic-cognitive syndrome" (MCS) in patients with MetS plus cognitive impairment of degenerative or vascular origin. In particular, MetS has been associated with the risk of age-related cognitive decline and vascular dementia, but contrasting findings also existed on the possible role of MetS in overall dementia and Alzheimer's disease. Among metabolic determinants of cognitive impairment, a better approach to the understanding of mechanisms could be to hypothesize a continuum leading to various degrees of late-life cognitive disorders in older subjects with metabolic-based risk factors. The MCS model could help us to explain the complex relationship between metabolic disorders and cognitive disturbances and the boundaries between normal and pathological conditions, with a better understanding of clinical and neuropathological features of these metabolic-b...Continue Reading
Citations
Nov 23, 2012·Diabetes Care·Keigo ShimojiShigeki Aoki
May 16, 2015·Molecular Neurobiology·Juan F CodocedoNibaldo C Inestrosa
Mar 1, 2016·International Journal of Geriatric Psychiatry·Elvira LaraJosep Maria Haro
Mar 27, 2015·Rejuvenation Research·Francesco PanzaGiancarlo Logroscino
Feb 6, 2017·Circulation Research·Martin Dichgans, Didier Leys
Jul 6, 2018·Menopause : the Journal of the North American Menopause Society·Roksana KarimWendy J Mack
Feb 17, 2018·Chinese Medical Journal·Rui LiJing Xu
Aug 8, 2013·Nature Medicine·Ralph A Nixon
Aug 12, 2014·Expert Review of Neurotherapeutics·Masafumi Ihara, Raj N Kalaria
Dec 4, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Fred R SattlerUNKNOWN CHARTER Group
Dec 23, 2014·Neurodegenerative Disease Management·Kurt A Jellinger
Aug 26, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michal Schnaider BeeriAnthony Heymann
May 7, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sid E O'BryantMeharvan Singh
Apr 29, 2015·Age and Ageing·Emmanuelle Kesse-GuyotPilar Galan
Mar 4, 2015·The Journal of Nutrition, Health & Aging·F PanzaG Logroscino
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Francesco PanzaGiancarlo Logroscino
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Francesco PanzaGiancarlo Logroscino
Jan 13, 2019·Journal of Neurovirology·Lucette A Cysique, Bruce J Brew
Oct 27, 2018·ELife·Julia C KörholzGerd Kempermann
Sep 21, 2018·Frontiers in Neuroscience·Ana P S DornellasEliane B Ribeiro
Feb 11, 2021·Nutrients·Francesco FisicaroRita Bella
Jul 3, 2021·Nutrients·Milagros RojasEdgar Díaz-Camargo