Current evidence for focal therapy and partial gland ablation for organ-confined prostate cancer: systematic review of literature published in the last 2 years.

Current Opinion in Urology
Paulo Priante Kayano, Laurence Klotz

Abstract

The shift in the diagnostic algorithm for prostate cancer to early imaging with mpMRI has resulted in many patients being diagnosed with small volume, apparently unilateral, clinically significant cancers. In these patients, a minimally invasive, nonmorbid intervention is appealing. The aim of this study was to review data reported within the last 2 years on focal therapy and partial gland ablation for organ-confined prostate cancer. High-intensity focal ultrasound, focal cryotherapy, photodynamic therapy, irreversible electroporation and focal laser ablation, have been used as treatment modalities for localized prostate cancer treatment. The reported oncologic outcomes vary widely and makes comparisons challenging. All the focal therapies report low rates of complications, and high rates of continence and erectile function preservation. The most common adverse events are hematuria, urinary retention and urinary tract infections. During this period, the initial results of several new technologies including MRI-guided transurethral ultrasound ablation were published. Focal therapy and partial gland ablation for organ-confined prostate cancer is an option for patients with intermediate-risk disease because of its low complication...Continue Reading

References

Oct 27, 1998·Cryobiology·A A Gage, J Baust
Mar 18, 2005·Annals of Biomedical Engineering·R V DavalosB Rubinsky
Jan 21, 2014·European Urology·Stacy LoebRuth Etzioni
Mar 7, 2014·The New England Journal of Medicine·Anna Bill-AxelsonJan-Erik Johansson
Jan 10, 2016·The Journal of Urology·Shyam NatarajanLeonard S Marks
Sep 15, 2016·The New England Journal of Medicine·Freddie C HamdyUNKNOWN ProtecT Study Group
Mar 20, 2018·The New England Journal of Medicine·Veeru KasivisvanathanUNKNOWN PRECISION Study Group Collaborators
May 23, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Peter H Carroll, James L Mohler
Sep 6, 2018·European Urology·Marthe LøvfRolf I Skotheim
Sep 14, 2018·Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology·Matthijs J ScheltemaPhillip D Stricker
Mar 2, 2019·Journal of Vascular and Interventional Radiology : JVIR·Eric WalserStephen B Williams
Aug 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ardeshir R RastinehadNaomi J Halas
Sep 27, 2019·Scandinavian Journal of Urology·Mikael AnttinenPeter J Boström
Jan 9, 2020·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jun 4, 2020·World Journal of Urology·Alexandar BlazevskiPhillip D Stricker
Jul 24, 2020·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Laurence KlotzEric Klein
Oct 7, 2020·The Journal of Urology·Laurence KlotzScott Eggener

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Urology
Ryan P Werntz, Scott Eggener
Current Opinion in Oncology
Michael AhdootPeter A Pinto
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
David J Habibian, Aaron Katz
Nature Reviews. Urology
Marlon PereraNathan Lawrentschuk
© 2021 Meta ULC. All rights reserved