Current guidelines on prevention with a focus on dyslipidemias

Cardiovascular Diagnosis and Therapy
Ian M GrahamNathan D Wong

Abstract

Examination of the current the American College of Cardiology/American Heart Association (ACC/AHA) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines on the prevention of cardiovascular disease and the management of dyslipidemias finds much common ground. Both note that Atherosclerotic cardiovascular disease (ASCVD) is, in most people, the product of a number of risk factors, notably tobacco exposure, hyperlipidemia, hypertension, inactivity, overweight and diabetes. They stress that risk calculators can help in the assessment of risk in apparently healthy persons. Persons with established ASCVD and many with diabetes or renal impairment are at high to very high risk and warrant intensive risk factor advice and guideline-based preventive therapies. The ACC/AHA guidelines favor the universal use of statins in all high-risk subjects and in primary prevention where the global risk exceeds 7.5% in 10 years, with a percentage reduction in low-density lipoprotein cholesterol (LDL-C) based on statin intensity as the "goal". In contrast, the ESC/EAS guidelines favor a goal or percentage-based reduction in LDL-C based on total risk and baseline LDL-C level. Both guidelines consider certain imaging a...Continue Reading

Citations

Sep 9, 2017·International Journal of Molecular Sciences·Xu WangYi Feng
Dec 13, 2017·Expert Opinion on Drug Metabolism & Toxicology·Arrigo F G CiceroClaudio Borghi
Mar 8, 2019·Expert Opinion on Emerging Drugs·Marilisa BoveClaudio Borghi
Mar 21, 2018·Current Medicinal Chemistry·Alexander N Orekhov, Igor A Sobenin
Mar 31, 2018·Expert Opinion on Drug Discovery·Isabelle CoornaertWim Martinet
Aug 21, 2019·Experimental Biology and Medicine·Hamiyet Donmez-AltuntasPeter P Toth

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