Current HIV treatment guidelines--an overview

Current Pharmaceutical Design
R C RathbunJ R Stephens

Abstract

Use of highly active antiretroviral therapy has resulted in significant reductions in HIV-related morbidity and mortality. Current therapeutic approaches target cellular entry, viral transcription, and maturation of newly formed virus. Combination therapy is necessary to provide durable suppression of viral replication and immune reconstitution. A variety of consensus treatment guidelines addressing prophylaxis and treatment of HIV infection and opportunistic infections have been developed to serve as resources for clinicians. A summary of U.S. Department of Health and Human Services Guidelines for Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents and International AIDS Society-USA Panel recommendations for Treatment of Adult HIV infection are presented. Considerations for selection of antiretroviral therapy in special populations (e.g., pregnancy, coinfection with tuberculosis, hepatitis B and C virus) are highlighted. U.S. Public Health Service guidelines for management of occupational exposure to HIV and initiation of postexposure prophylaxis are discussed as well as World Health Organization recommendations for use of antiretroviral therapy in resource-limited settings. The pathophysiology of HIV infecti...Continue Reading

Citations

Jun 22, 2007·The New England Journal of Medicine·Moira A McMahonChloe L Thio
Aug 19, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Erdembileg AnuuradLars Berglund
Apr 25, 2013·Antimicrobial Agents and Chemotherapy·Nagsen GautamYazen Alnouti
Dec 29, 2009·Frontiers in Bioscience (Elite Edition)·J Jack LeeMaiying Kong
May 28, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Brian Thabile FlepisiBernd Rosenkranz
Feb 7, 2014·Drug Development and Industrial Pharmacy·Sanjeev RambharoseThirumala Govender
Aug 23, 2008·Drug Delivery·T GovenderI Mackraj
Jul 29, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Elizabeth OjewoleThirumala Govender
May 24, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Koji FukushimaTooru Shimosegawa
Dec 6, 2006·Annals of the New York Academy of Sciences·Mingjie LiJohn J Rossi
Nov 23, 2006·Bioorganic & Medicinal Chemistry Letters·Rena NishizawaHiroaki Mitsuya
Oct 8, 2014·Antimicrobial Agents and Chemotherapy·Nagsen GautamYazen Alnouti
Feb 3, 2007·Expert Review of Anti-infective Therapy·Damjan S NikolicVincent Piguet
Jan 30, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Suzanne M BoyleDong Heun Lee
Oct 5, 2018·JCI Insight·Amanda B MacedoAlberto Bosque
Aug 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sanjeev RambharoseThirumala Govender
May 7, 2016·Journal of HIV/AIDS & Social Services·Geoffrey MainaVera Caine
Sep 22, 2020·Expert Opinion on Pharmacotherapy·Anam TariqMohamed G Atta
Jun 19, 2009·Journal of Medicinal Chemistry·Rong-Jian LuConnie Sexton
Jan 27, 2012·ACS Chemical Biology·Varun DewanKarin Musier-Forsyth
Dec 3, 2021·Journal of Medicinal Chemistry·Xiao-Fei ChenZifeng Yang

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