Current Insights into Oral Cancer Epigenetics

International Journal of Molecular Sciences
Alexandra Iulia IrimieIoana Berindan-Neagoe

Abstract

Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the concept of malignant pathologies as being solely genetic-based conditions. The epigenetic landscape is responsible for normal development but also for the heterogeneity among tissues in terms of gene expression patterns. Dysregulation in these mechanisms has been associated with disease stage, and increased attention is now granted to cancer in order to take advantage of these modifications in terms of novel therapeutic strategies or diagnosis/prognosis tools. Oral cancer has also been subjected to epigenetic analysis with numerous studies revealing that the development and progression of this malignancy are partially induced by an altered epigenetic substrate together with genetic alterations and prolonged exposure to environmental risk factors. The present review summarizes the most important epigenetic modifications associated with oral cancer and also their potential to be used as new therapeutic targets.

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Citations

Aug 6, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Kai-Liang TangShi-Jiang Xiong
Jun 9, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Chao HuangCungang Wu
Sep 21, 2020·Medical Molecular Morphology·Bhoj Raj AdhikariYoshihiro Abiko
Dec 22, 2019·Cells·Óscar Rapado-GonzálezMaría Mercedes Suárez-Cunqueiro
Oct 23, 2020·Journal of Dental Research·M Y ChenY L Chen
Apr 17, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel
Apr 14, 2021·Annals of Surgical Oncology·Zuzana SaidakAntoine Galmiche
Jun 5, 2021·Head & Face Medicine·Bing WangZhong-Cheng Gong
Jun 21, 2021·Critical Reviews in Oncology/hematology·Carolina Simão FlausinoFilipe Modolo
Sep 18, 2021·Cancer Investigation·Naila MalkaniMuhammad Usman Rashid

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Methods Mentioned

BETA
genetic modifications
acetylation
histone acetylation

Clinical Trials Mentioned

NCT00901537
NCT00443261

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