PMID: 25743790Mar 7, 2015Paper

Current insights on cholangiocarcinoma research: a brief review

Asian Pacific Journal of Cancer Prevention : APJCP
Vivek Bhakta Mathema, Kesara Na-Bangchang

Abstract

Colangiocarcinoma (CCA) is a progressively fatal disease which generally occurs due to malignant transformation of hepatic biliary cholangiocytes. The incidence of CCA has been increasing worldwide and there is an urgent requirement for effective diagnosis and treatment strategies against this devastating disease. Different factors including liver-fluke infestation, viral hepatitis, exogenous nitrosamine-mediated DNA damage, and chronic inflammation have been linked to CCA genesis. However, the risk factors and underlying complex mechanisms leading to development of CCA are not sufficiently understood to devise an effective targeted treatment therapy. In this review, we summarize currently known epidemiological and pathological aspects of the disease and briefly describe various potential biomarkers and experimental anticancer phytochemicals related to CCA research. In addition, we also sum up recent findings that link chronic inflammation of hepatic biliary cholangiocytes with CCA. The collective information concisely presented in this article would provide useful insights into the current understanding of this cancer.

References

Apr 2, 2004·The American Journal of Gastroenterology·Kelly BurakKeith D Lindor
Jun 12, 2004·Seminars in Liver Disease·Yasser Shaib, Hashem B El-Serag
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sang Woo OhSoon-Ae Shin
Jan 13, 2006·International Journal of Cancer. Journal International Du Cancer·Donald Maxwell Parkin
Sep 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Muller FabbriCarlo M Croce
Feb 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Junji KomoriTsutomu Chiba
Apr 15, 2008·Current Opinion in Gastroenterology·Banchob Sripa, Chawalit Pairojkul
Nov 26, 2008·World Journal of Gastroenterology : WJG·Yucel Ustundag, Yusuf Bayraktar
Apr 28, 2009·Current Opinion in Gastroenterology·Domenico Alvaro
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Oct 6, 2010·BMC Complementary and Alternative Medicine·Wiratchanee MahavorasirikulKesara Na-Bangchang
Apr 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gia L Tyson, Hashem B El-Serag
Apr 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sujit S NairRakesh Kumar
Aug 3, 2011·Nature Reviews. Gastroenterology & Hepatology·Boris BlechaczGregory J Gores
Dec 17, 2011·Journal of Hepatology·Shahid A KhanMireille B Toledano
Feb 11, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Wongwarut BoonyanugomolAmporn Chamsuwan
Mar 1, 2012·Asia-Pacific Journal of Clinical Oncology·Zhenliang QuXianzhong Wu
Sep 18, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nataliya Razumilava, Gregory J Gores
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Tullayakorn PlengsuriyakarnKesara Na-Bangchang
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Pattaravadee SrikoonSeiji Okada
Dec 25, 2013·The Journal of International Medical Research·Denghua YaoXiao Li
Jan 1, 2014·International Journal of Clinical Practice·M XiaoY Wang
Apr 4, 2014·Internal Medicine·Kazuya MatsumotoYoshikazu Murawaki
Apr 24, 2014·Japanese Journal of Clinical Oncology·Hiroyuki TakahashiTatsuhiro Shibata
Jun 11, 2014·World Journal of Gastroenterology : WJG·Hua-Bang ZhouHe-Ping Hu
Jul 8, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ploypailin AneknanLaddawan Senggunprai
Jul 10, 2014·Nature Communications·Neil D YoungRobin B Gasser
Jul 22, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Pokpong PrayongBanchob Sripa
Jul 30, 2014·Asian Pacific Journal of Tropical Medicine·Nut KoonrungsesomboonJuntra Karbwang

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Citations

Jan 16, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Giovanni BrandiUNKNOWN GICO
Dec 14, 2016·BioMed Research International·Christian MayrTobias Kiesslich
Sep 30, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xianhai MaoBo Jiang

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