Current international initiatives in antiphospholipid antibody testing

Seminars in Thrombosis and Hemostasis
Rohan WillisSilvia S Pierangeli

Abstract

Positive results in the anticardiolipin antibody (aCL), anti-β2-glycoprotein I antibody (aβ2GPI), and/or lupus anticoagulant (LA) assays constitute the laboratory criteria for the definite diagnosis of the antiphospholipid syndrome (APS). These tests became available from as early as the1980s, and since then several novel assays have become available that have varied usefulness in the diagnosis and prognosis of APS patients. For almost three decades there has been an ongoing effort to standardize the aCL, aβ2GPI, and LA assays, but there are still reports of significant intra- and interlaboratory variation in the results of all three assays. There have also been numerous issues with the implementation of novel (noncriteria) antiphospholipid antibody (aPL) tests in standard testing panels, due to either lack of standardized testing methods or limited evidence of their clinical utility in APS patients. At the recent 13th International Congress on Antiphospholipid Antibodies (APLA 2010, 13-16 April 2010, Galveston, TX), two task forces were set up to address these problems. This review gives a general description of current problems hindering the standardization of aPL tests and the implementation of novel assays as standard compo...Continue Reading

Citations

Jul 4, 2013·Southern Medical Journal·Pramod Reddy
Apr 18, 2013·International Journal of Laboratory Hematology·E J Favaloro
Apr 23, 2014·International Journal of Laboratory Hematology·K M J Devreese
Sep 17, 2015·Thrombosis Research·Teresa IwaniecJacek Musiał
Feb 20, 2015·Hematology·Steven A Krilis, Bill Giannakopoulos
Jan 9, 2019·Expert Review of Clinical Immunology·Amelia RuffattiTeresa Del Ross
Oct 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Emmanuel J Favaloro

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.